Abstract
Oligosaccharides from human milk samples obtained from individual donors were analyzed using high-pH anion-exchange chromatography. Three patterns of neutral oligosaccharides were detected corresponding to milk groups already described. These oligosaccharide groups correspond to the Lewis blood types Lea-b+Lea+b-and Lea-b-. A new carbohydrate pattern was detected in a milk sample from a Lea-b-person in which only nonfucosylated oligosaccharides and compounds bearing al,3-linked fucosyl residues were found. This finding led to the hypothesis that there exist 4 different oligosaccharide milk groups that fit well to the genetic basis of the Lewis blood group system.
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Stahl, B., Thurl, S., Henker, J., Siegel, M., Finke, B., Sawatzki, G. (2001). Detection of Four Human Milk Groups with Respect to Lewis-Bloodgroup-Dependent Oligosaccharides by Serologic and Chromatographic Analysis. In: Newburg, D.S. (eds) Bioactive Components of Human Milk. Advances in Experimental Medicine and Biology, vol 501. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1371-1_37
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DOI: https://doi.org/10.1007/978-1-4615-1371-1_37
Publisher Name: Springer, Boston, MA
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