Abstract
Microglial cells are ontogenetically related to the cells of the mononuclear phagocyte lineage, unlike all the other cells types in the CNS, and are widely spread throughout the brain. In normal brain, resting microglia show a downregulated phenotype adapted to the specialised microenvironment of the CNS. However, they can be rapidly activated to become important effector cells in most brain pathologies. Depending on the type or intensity of the stimulus and the concurrence of other local factors, they may foster neuroprotective and repair processes as well as contribute to the establishment and/or the amplification of tissue damage1.
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Minghetti, L., Nicolini, A., Polazzi, E., Créminon, C., Maclouf, J., Levi, G. (1997). Prostaglandin E2 Downregulates Inducible Nitric Oxide Synthase Expression in Microglia by Increasing cAMP Levels. In: Sinzinger, H., Samuelsson, B., Vane, J.R., Paoletti, R., Ramwell, P., Wong, P.YK. (eds) Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research. Advances in Experimental Medicine and Biology, vol 433. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1810-9_37
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DOI: https://doi.org/10.1007/978-1-4899-1810-9_37
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