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Epidemiology of Stomach Cancer

  • Protocol
Book cover Cancer Epidemiology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 472))

Abstract

Despite a major decline in incidence and mortality over several decades, stomach cancer is still the fourth most common cancer and the second most common cause of cancer death in the world. There is a 10-fold variation in incidence between populations at the highest and lowest risk. The incidence is particularly high in East Asia, Eastern Europe, and parts of Central and South America, and it is about twice as high among men than among women. Prognosis is generally rather poor, with 5-year relative survival below 30% in most countries. The best established risk factors for stomach cancer are Helicobacter pylori infection, the by far strongest established risk factor for distal stomach cancer, and male sex, a family history of stomach cancer, and smoking. While some factors related to diet and food preservation, such as high intake of salt-preserved foods and dietary nitrite or low intake of fruit and vegetables, are likely to increase the risk of stomach cancer, the quantitative impact of many dietary factors remains uncertain, partly due to limitations of exposure assessment and control for confounding factors. Future epidemiologic research should pay particular attention to differentiation of stomach cancer epidemiology by subsite, and to exploration of potential interactions between H. pylori infection, genetic, and environmental factors.

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References

  1. Ferlay, J., Bray, F., Pisani, P., and Parkin, D. M. (2004) GLOBOCAN 2002: Cancer incidence, mortality and prevalence worldwide. IARC CancerBase No. 5. Version 2.0, IARC Press, Lyon, France [online available from http://www-dep.iarc.fr]

  2. International Agency for Research on Cancer, World Health Organization (1994) Infection with Helicobacter pylori, in Schistosomes, liver flukes and Helicobacter pylori, IARC Monogr. Eval. Carcinog. Risks Hum. Vol. 60, Lyon, France, pp. 177–240.

    Google Scholar 

  3. Campbell, D. I., Warren, B. F., Thomas, J. E., Figura, N., Telford, J. L., and Sullivan, P. B. (2001) The African enigma: low prevalence of gastric atrophy, high prevalence of chronic inflammation in West African adults and children.Helicobacter.6, 263–267.

    Article  CAS  PubMed  Google Scholar 

  4. Brenner, H. (2002) Long-term survival rates of cancer patients achieved by the end of the 20th century: a period analysis.Lancet 360, 1131–1135.

    Article  PubMed  Google Scholar 

  5. Parkin, D. M., Bray, F., Ferlay, J., and Pisani, P. (2005) Global cancer statistics, 2002.CA Cancer J. Clin.55, 74–108.

    Article  PubMed  Google Scholar 

  6. Forman, D. and Burley, V. J. (2006) Gastric cancer: global pattern of the disease and an overview of environmental risk factors.Best Pract. Res. Clin. Gastroenterol.20, 633–649.

    Article  CAS  PubMed  Google Scholar 

  7. Parkin, D. M., Whelan, S. L., Ferlay, J., and Storm, H. (2005) Cancer incidence in five continents, Vol I to VIII, IARC CancerBase No. 7, IARC Press, Lyon, France [online available fromhttp://www-dep.iarc.fr

  8. Berrino, F. (2003) The EUROCARE Study: strengths, limitations and perspectives of population-based, comparative survival studies.Ann. Oncol.14Suppl 5, v9–13.

    Article  PubMed  Google Scholar 

  9. Gatta, G., Capocaccia, R., Coleman, M. P., Gloeckler Ries, L. A., Hakulinen, T., Micheli, A., Sant, M., Verdecchia, A., and Berrino, F. (2000) Toward a comparison of survival in American and European cancer patients.Cancer 89, 893–900.

    Article  CAS  PubMed  Google Scholar 

  10. Verdecchia, A., Mariotto, A., Gatta, G., Bustamante-Teixeira, M. T., and Ajiki, W. (2003) Comparison of stomach cancer incidence and survival in four continents.Eur. J. Cancer 39, 1603–1609.

    Article  CAS  PubMed  Google Scholar 

  11. Crew, K. D. and Neugut, A. I. (2006) Epidemiology of gastric cancer.World J. Gastroenterol.12, 354–362.

    PubMed  Google Scholar 

  12. Banatvala, N., Mayo, K., Megraud, F., Jennings, R., Deeks, J. J., and Feldman, R. A. (1993) The cohort effect andHelicobacter pylori. J. Infect. Dis. 168, 219–221.

    CAS  PubMed  Google Scholar 

  13. Roosendaal, R., Kuipers, E. J., Buitenwerf, J., van Uffelen, C., Meuwissen, S. G., van Kamp, G. J., and Vandenbroucke-Grauls, C. M. (1997)Helicobacter pyloriand the birth cohort effect: evidence of a continuous decrease of infection rates in childhood.Am. J. Gastroenterol.92, 1480–1482.

    CAS  PubMed  Google Scholar 

  14. Marshall, B. J. and Warren, J. R. (1984) Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration.Lancet 1, 1311–1315.

    Article  CAS  PubMed  Google Scholar 

  15. Helicobacter pylori and Cancer Collaborative Group (2001) Gastric cancer andHelicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts.Gut 49, 347–353.

    Article  Google Scholar 

  16. Ekström, A. M., Held, M., Hansson, L. E., Engstrand, L., and Nyren, O. (2001)Helicobacter pyloriin gastric cancer established by CagA immunoblot as a marker of past infection.Gastroenterology 121, 784–791.

    Article  PubMed  Google Scholar 

  17. Brenner, H., Arndt, V., Stegmaier, C., Ziegler, H., and Rothenbacher, D. (2004) IsHelicobacter pyloriinfection a necessary condition for noncardia gastric cancer?Am. J. Epidemiol.159, 252–258.

    Article  PubMed  Google Scholar 

  18. Rothenbacher, D. and Brenner, H. (2003) Burden ofHelicobacter pyloriandH. pylori-related diseases in developed countries: recent developments and future implications.Microbes Infect. 5, 693–703.

    Article  PubMed  Google Scholar 

  19. Huang, J. Q., Zheng, G. F., Sumanac, K., Irvine, E. J., and Hunt, R. H. (2003) Metaanalysis of the relationship between cagA seropositivity and gastric cancer.Gastroen-terology 125, 1636–1644.

    Article  Google Scholar 

  20. El-Omar, E. M., Rabkin, C. S., Gammon, M. D., Vaughan, T. L., Risch, H. A., Sch-oenberg, J. B., Stanford, J. L., Mayne, S. T., Goedert, J., Blot, W. J., Fraumeni, J. F., Jr., and Chow, W. H. (2003) Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms.Gastroenterology 124, 1193–1201.

    Article  CAS  PubMed  Google Scholar 

  21. Brenner, H., Arndt, V., Bode, G., Stegmaier, C., Ziegler, H., and Stumer, T. (2002) Risk of gastric cancer among smokers infected withHelicobacter pylori. Int. J. Cancer 98, 446–449.

    Article  CAS  PubMed  Google Scholar 

  22. Brenner, H., Arndt, V., Stürmer, T., Steg-maier, C., Ziegler, H., and Dhom, G. (2000) Individual and joint contribution of family history andHelicobacter pyloriinfection to the risk of gastric carcinoma.Cancer 88, 274–279.

    Article  CAS  PubMed  Google Scholar 

  23. Rothenbacher, D., Inceoglu, J., Bode, G., and Brenner, H. (2000) Acquisition ofHeli-cobacter pyloriinfection in a high-risk population occurs within the first 2 years of life.J. Pediatr. 136, 744–748.

    Article  CAS  PubMed  Google Scholar 

  24. Rothenbacher, D., Bode, G., and Brenner, H. (2002) Dynamics ofHelicobacter pyloriinfection in early childhood in a high-risk group living in Germany: loss of infection higher than acquisition.Aliment. Pharmacol. Ther. 16, 1663–1668.

    Article  CAS  PubMed  Google Scholar 

  25. Weyermann, M., Adler, G., Brenner, H., and Rothenbacher, D. (2006) The mother as source ofHelicobacter pyloriinfection.Epidemiology 17, 332–334.

    Article  PubMed  Google Scholar 

  26. Wong, B. C., Lam, S. K., Wong, W. M., Chen, J. S., Zheng, T. T., Feng, R. E., Lai, K. C., Hu, W. H., Yuen, S. T., Leung, S. Y., Fong, D. Y., Ho, J., Ching, C. K., and Chen, J. S. (2004)Helicobacter pylorieradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial.JAMA 291, 187–194.

    Article  CAS  PubMed  Google Scholar 

  27. Fuccio, L., Zagari, R. M., Minardi, M. E., and Bazzoli, F. (2007) Systematic review:Helicobacter pylorieradication for the prevention of gastric cancer.Aliment. Pharmacol. Ther. 25, 133–141.

    Article  CAS  PubMed  Google Scholar 

  28. Kamineni, A., Williams, M. A., Schwartz, S. M., Cook, L. S., and Weiss, N. S. (1999) The incidence of gastric carcinoma in Asian migrants to the United States and their descendants.Cancer Causes Control 10, 77–83.

    Article  CAS  PubMed  Google Scholar 

  29. Jakszyn, P. and Gonzalez, C. A. (2006) Nit-rosamine and related food intake and gastric and oesophageal cancer risk: a systematic review of the epidemiological evidence.World J. Gastroenterol.12, 4296–4303.

    CAS  PubMed  Google Scholar 

  30. Riboli, E. and Norat, T. (2003) Epidemio-logic evidence of the protective effect of fruit and vegetables on cancer risk.Am. J. Clin. Nutr. 78, 559S–569S.

    CAS  PubMed  Google Scholar 

  31. Gonzalez, C. A., Pera, G., Agudo, A., Bueno-de-Mesquita, H. B., Ceroti, M., Boeing, H., Schulz, M., Del Giudice, G., Plebani, M., Carneiro, F., Berrino, F., Sacer-dote, C., Tumino, R., Panico, S., Berglund, G., Siman, H., Hallmans, G., Stenling, R., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J. R., Allen, N., Key, T. J., Bingham, S., Day, N. E., Lin-seisen, J., Nagel, G., Overvad, K., Jensen, M. K., Olsen, A., Tjonneland, A., Buchner, F. L., Peeters, P. H., Numans, M. E., Clavel-Chapelon, F., Boutron-Ruault, M. C., Rou-kos, D., Trichopoulou, A., Psaltopoulou, T., Lund, E., Casagrande, C., Slimani, N., Jenab, M., and Riboli, E. (2006) Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).Int. J. Cancer 118, 2559–2566.

    Article  CAS  PubMed  Google Scholar 

  32. Gonzalez, C. A., Jakszyn, P., Pera, G., Agudo, A., Bingham, S., Palli, D., Ferrari, P., Boeing, H., del Giudice, G., Plebani, M., Carneiro, F., Nesi, G., Berrino, F., Sacer-dote, C., Tumino, R., Panico, S., Berglund, G., Siman, H., Nyren, O., Hallmans, G., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J. R., Allen, N., Key, T. J., Day, N. E., Linseisen, J., Nagel, G., Bergmann, M. M., Overvad, K., Jensen, M. K., Tjonneland, A., Olsen, A., Bueno-de-Mesquita, H. B., Ocke, M., Peeters, P. H., Numans, M. E., Clavel-Chapelon, F., Boutron-Ruault, M. C., Trichopoulou, A., Psaltopoulou, T., Roukos, D., Lund, E., Hemon, B., Kaaks, R., Norat, T., and Riboli, E. (2006) Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC).J. Natl. Cancer Inst. 98, 345–354.

    Article  PubMed  Google Scholar 

  33. Jacobs, E. J., Connell, C. J., McCullough, M. L., Chao, A., Jonas, C. R., Rodriguez, C., Calle, E. E., and Thun, M. J. (2002) Vitamin C, vitamin E, and multivitamin supplement use and stomach cancer mortality in the Cancer Prevention Study II cohort.Cancer Epidemiol. Biomarkers Prev. 11, 35–41.

    CAS  PubMed  Google Scholar 

  34. Gonzalez, C. A., Pera, G., Agudo, A., Palli, D., Krogh, V., Vineis, P., Tumino, R., Pan-ico, S., Berglund, G., Siman, H., Nyren, O., Agren, A., Martinez, C., Dorronsoro, M., Barricarte, A., Tormo, M. J., Quiros, J. R., Allen, N., Bingham, S., Day, N., Miller, A., Nagel, G., Boeing, H., Overvad, K., Tjonneland, A., Bueno-De-Mesquita, H. B., Boshuizen, H. C., Peeters, P., Numans, M., Clavel-Chapelon, F., Helen, I., Agapi-tos, E., Lund, E., Fahey, M., Saracci, R., Kaaks, R., and Riboli, E. (2003) Smoking and the risk of gastric cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC).Int. J. Cancer 107, 629–634.

    Article  CAS  PubMed  Google Scholar 

  35. Brinton, L. A., Gridley, G., Hrubec, Z., Hoover, R., and Fraumeni, J. F., Jr. (1989) Cancer risk following pernicious anaemia.Br. J. Cancer 59, 810–813.

    CAS  PubMed  Google Scholar 

  36. Wang, W. H., Huang, J. Q., Zheng, G. F., Lam, S. K., Karlberg, J., and Wong, B. C. (2003) Non-steroidal anti-inflammatory drug use and the risk of gastric cancer: a systematic review and meta-analysis.J. Natl. Cancer Inst. 95, 1784–1791.

    CAS  PubMed  Google Scholar 

  37. Brenner, H., Bode, G., and Boeing, H. (2000)Helicobacter pyloriinfection among offspring of patients with stomach cancer.Gastroenterology 118, 31–35.

    Article  CAS  PubMed  Google Scholar 

  38. Calle, E. E., Rodriguez, C., Walker-Thurmond, K., and Thun, M. J. (2003) Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.N. Engl. J. Med. 348, 1625–1638.

    Article  PubMed  Google Scholar 

  39. Raj, A., Mayberry, J. F., and Podas, T. (2003) Occupation and gastric cancer.Postgrad. Med. J. 79, 252–258.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany

    Hermann Brenner, Dietrich Rothenbacher & Volker Arndt

Authors
  1. Hermann Brenner
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  2. Dietrich Rothenbacher
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  3. Volker Arndt
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Editor information

Editors and Affiliations

  1. Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, 20892, USA

    Mukesh Verma PhD

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Brenner, H., Rothenbacher, D., Arndt, V. (2009). Epidemiology of Stomach Cancer. In: Verma, M. (eds) Cancer Epidemiology. Methods in Molecular Biology, vol 472. Humana Press. https://doi.org/10.1007/978-1-60327-492-0_23

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  • DOI: https://doi.org/10.1007/978-1-60327-492-0_23

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-491-3

  • Online ISBN: 978-1-60327-492-0

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