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Reproductive factors and colon cancer: the influences of age, tumor site, and family history on risk (Utah, United States)

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The Utah (United States) Population Database was used to evaluate the associations between reproductive factors and colon cancer risk and the impact that family history, age at diagnosis, and tumor site have on these associations. From the cohort of (White) women in the database, all first-primary cases of colon cancer (n=819) and controls who had complete fertility information (n=3, 202) were examined. The majority of tumors (68.6 percent) among women diagnosed at age 64 years or less were in the distal segment of the colon, while among women 65 or older, the majority of tumors (55.7 percent) were proximal. Women diagnosed before age 65 had a lower risk of colon cancer with increasing numbers of liveborn children (odds ratio [OR]=0.6, 95 percent confidence interval [CI]=0.3–0.9 for women with five or more children compared with women with one or two children). A long interval between first and second births (first birth-interval) was associated with increased risk of tumors in the distal segment of the colon (OR=1.4, CI=1.0–2.0) and among women diagnosed before age 65 (OR=1.6, CI=1.0–2.5); a longer, average birth-interval was associated with increased risk of proximal tumors (OR=1.5, CI=1.1–2.1). A longer, first birth-interval increased the risk associated with a family history of colon cancer, as did a longer average birth-interval and an older age at first or last birth. From these data, it appears that reproductive factors have heterogeneous effects on the risk of colon cancer that vary with age at diagnosis, tumor site, and family history of disease.

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References

  1. Fraumeni JFJr, Lloyd JW, Smith EM, Wagoner JK. Cancer mortality among nuns: Role of marital status in etiology of neoplastic disease in women. JNCI 1969; 42 455–68.

    Google Scholar 

  2. McMichael AJ, Potter JD. Reproduction, endogenous and exogenous sex hormones, and colon cancer risk: A review and a hypothesis. JNCI 1980; 65 1201–7.

    Google Scholar 

  3. Potter JD, McMichael AJ. Large bowel cancer in women in relation to reproductive and hormonal factors: A case-control study. JNCI 1983; 71 703–9.

    Google Scholar 

  4. Bjelke E. Epidemiologic studies of cancer of the stomach, colon, and rectum. Scand J Gastroenterol 1974; 9 31S: 1.

    Google Scholar 

  5. Peters RK, Pike MC, Chang WWL, Mack TM. Reproductive factors and colon cancer. Br J Cancer 1990; 61: 741–8.

    Google Scholar 

  6. Kune GA, Kune S, Watson LF. Children, age at first birth and colorectal cancer risk: data from the Melbourne Colorectal Cancer Study. Am J Epidemiol 1989; 129: 533–42.

    Google Scholar 

  7. Wu-Williams AH, Lee M, Whittemore AS, et al. Reproductive factors and colorectal cancer risk among Chinese females. Cancer Res 1991; 51: 2307–11.

    Google Scholar 

  8. Chute CG, Willett WC, Colditz GA, Stampfer MJ, Rosner B, Speizer FE. A prospective study of reproductive history and exogenous estrogens on the risk of colorectal cancer in women. Epidemiology 1991; 2: 201–7.

    Google Scholar 

  9. Gerhardsson de Verdier M, London S. Reproductive factors, exogenous female hormones, and colorectal cancer by subsite. Cancer Causes Control 1992; 3 355–60.

    Google Scholar 

  10. Howe GR, Craib KJP, Miller AB. Age at first pregnancy and risk of colorectal cancer: a case-control study. JNCI 1985; 74 1155–9.

    Google Scholar 

  11. Plesko I, Preston-Martin S, Day NE, Tzonou A, Dimitrova E, Somogyi J. Parity and cancer risk in Slovakia. Int J Cancer 1985; 36 529–33.

    Google Scholar 

  12. Davis FG, Furner SE, Persky V, Koch M. The influence of parity and exogenous female hormones on the risk of colorectal cancer. Int J Cancer 1989; 43 587–90.

    Google Scholar 

  13. Negri E, La Vecchia C, Parazzini F, et al. Reproductive and menstrual factors and risk of colorectal cancer. Cancer Res 1989; 49 7158–61.

    Google Scholar 

  14. World Health Organization. International Classification of Diseases for Oncology, First Edition. Geneva, Switzerland: WHO, 1976.

    Google Scholar 

  15. Skolnick M. The Utah genealogical database: a resource for genetic epidemiology. In: Cairns J, Lyon JL, Skolnick M, eds. Cancer Incidence in Defined Populations. Cold Spring Harbor, NY (USA): Cold Spring Harbor Laboratory, 1980.

    Google Scholar 

  16. Bean LL, Mineau GP, Anderton DL. Fertility Change on the American Frontier. Berkeley, CA (USA): University of California Press, 1990.

    Google Scholar 

  17. Thornton A. Religion and fertility: the case of Mormonism. J Marriage Fam 1979; 41 131–42.

    Google Scholar 

  18. Kerber RA. A method for calculating risk associated with family history of a disease. Genet Epidemiol 1995; 12, in press.

  19. Malecot G. Les Mathematiques de l'Heredite. Paris, France: Masson, 1948.

    Google Scholar 

  20. Breslow NE, Day NE. Statistical Methods in Cancer Research: the Design and Analysis of Cohort Studies, Vol. II. Lyon, France: International Agency for Research on Cancer, 1987; IARC Sci. Pub.. No. 82.

    Google Scholar 

  21. Slattery ML, Kerber RA. Family history of colon cancer and colon cancer risk: The Utah Population Disease. JNCI 1994; 86 1618–26.

    Google Scholar 

  22. Preston DL, Lubin JH, Pierce DA. EPICURE: Generalized Regression Models for Epidemiologic Data. Seattle, WA (USA): Hirosoft International, 1992.

    Google Scholar 

  23. Potter JD, Slattery ML, Bostick RM, Gasptur SM. Colon cancer: A review of the epidemiology. Epidemiol Rev 1993; 15 499–545.

    Google Scholar 

  24. Slattery ML, Potter JD, Sorenson AW. Age and risk factors for colon cancer (United States and Australia): Are there implications for understanding differences in case-control and cohort studies? Cancer Causes Control 1994; 5 557–63.

    Google Scholar 

  25. Cole P, Brown JB, MacMahon B. Oestrogen profiles of parous and nulliparous women. Lancet 1976; 2 596–9.

    Google Scholar 

  26. Trichopoulos D, Cole P, Brown JB, Goldman MB, MacMahon B. Estrogen profiles of primiparous and nulliparous women in Athens, Greece. JNCI 1980; 65 43–6.

    Google Scholar 

  27. Kwa HG, Cleton F, Bulbrook RD, Wang DY, Hayward JL. Plasma prolactin levels and breast cancer; relation to parity, weight and height, and age at first birth. Int J Cancer 1981; 28 31–4.

    Google Scholar 

  28. Bulfill JA. Colorectal cancer: Evidence for distinct genetic categories based on proximal or distal tumor location. Ann Med 1990; 113 779–88.

    Google Scholar 

  29. McMichael AJ, Potter JD. Host factors in carcinogenesis: Certain bile-acid profiles that selectively increase the risk of proximal colon cancer. JNCI 1985; 75 185–91.

    Google Scholar 

  30. Berkel J, Hombergen DAMA, Hooymayers IE, Faber JAJ. Cholecystectomy and colon cancer. Am J Gastroenterol 1990; 85 61–4.

    Google Scholar 

  31. Vernick LJ, Kuller HL, Soonthorn P, et al. Relationship between cholecystectomy and ascending colon cancer. Cancer 1980; 45 392–5.

    Google Scholar 

  32. Linos D, Beard CM, O'Fallon WM, et al. Cholecystectomy and carcinoma of the colon. Lancet 1981; 2 379–81.

    Google Scholar 

  33. Janerich DT, Thompson WD, Mineau GP. Maternal pattern of reproduction and risk of breast cancer in daughters: Results from the Utah Population Database. JNCI 1994; 86 1634–40.

    Google Scholar 

  34. Beral V. Parity and susceptibility to cancer. In: Evered D, Whelan J, eds. Fetal Antigens and Cancer. London, UK: Pittman, 1983; CIBA Foundations Symposium 96.

    Google Scholar 

  35. Medawar PB, Hunt R. Can fetal antigens be used for prophylactic immunization? In: Evered D, Whelan J, eds. Fetal Antigens and Cancer. London, UK: Pittman, 1983; CIBA Foundations Symposium 96.

    Google Scholar 

  36. Jacobs EJ, White E, Weiss NS: Exogenous hormones, reproductive history, and colon cancer. Cancer Causes Control 1994; 5 359–66.

    Google Scholar 

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This study was supported by grant and contract numbers CA48998 and CN0552 from the US National Cancer Institute. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Cancer Institute.

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Slattery, M.L., Mineau, G.P. & Kerber, R.A. Reproductive factors and colon cancer: the influences of age, tumor site, and family history on risk (Utah, United States). Cancer Causes Control 6, 332–338 (1995). https://doi.org/10.1007/BF00051408

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