Skip to main content
Log in

Anticentromere antibody — clinical associations

A study of 44 patients

  • Original Article
  • Published:
Rheumatology International Aims and scope Submit manuscript

Abstract

The objective of this study was to determine the clinical features of 44 patients with anticentromere antibody (ACA) positivity. We undertook a retrospective review of 44 ACA-positive patients (1 male and 43 females with a mean±SD age of 53.6±12.2 years). There were 25 patients with limited systemic sclerosis, 12 with Raynaud's disease, 2 with Sjögren's syndrome, 2 with systemic lupus erythematosus and 3 with polyarthritis. ACA was more frequently found in patients affected by limited systemic sclerosis with mild visceral involvement and in patients with Raynaud's disease. Moreover, ACA was detected in other connective tissue diseases that were characterized by an atypical autoantibody profile.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Weiner ES, Earnshaw WC, Senécal JL, Bordwell B, Johnson P, Rothfield NF (1988) Clinical associations of anticentromere antibodies and antibodies to topoisomerase. I. A study of 355 patients. Arthritis Rheum 31:378–385

    Google Scholar 

  2. Fritzler MJ, Kinsella TD, Garbutt E (1980) The CREST syndrome: a distinct serologic entity with anticentromere antibodies. Am J Med 69:520–526

    Google Scholar 

  3. Catoggio LJ, Skinner RP, Maddison PJ (1983) Frequency and clinical significance of anticentromere and anti-Scl-70 antibodies in an English connective tissue disease population. Rheumatol Int 3:19–21

    Google Scholar 

  4. LeRoy EC, Krieg T, Black C, Medsger TA Jr, Fleischmajer R, Rowell N, Jablonska S, Wollheim F (1988) Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 15:202–204

    Google Scholar 

  5. Vlachoyiannopoulos PG, Drosos AA, Wiik A, Moutsopoulos HM (1993) Patients with anticentromere antibodies, clinical features, diagnosis and evolution. Br J Rheumatol 32:297–301

    Google Scholar 

  6. Bernstein RM, Callender ME, Neuberger JM (1982) Anticentromere antibody in primary biliary cirrhosis. Ann Rheum Dis 41:612–614

    Google Scholar 

  7. Wade JP, Sack B, Schur PH (1988) Anticentromere antibodies—clinical correlates. J Rheumatol 15:1759–1763

    Google Scholar 

  8. Ferri C, Bernini L, Cecchetti R, Latorraca A, Marotta G, Pasero G, Neri R, Bombardieri S (1991) Cutaneous and serologic subsets of systemic sclerosis. J Rheumatol 18:1826–1832

    Google Scholar 

  9. Haberhauer G (1989) D-penicillamine (DPA)-induced anticentromere antibody (ACA). Clin Exp Rheumatol 7:332–334

    Google Scholar 

  10. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, Schaller JG, Talal N, Winchester RJ (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25:1271–1277

    Google Scholar 

  11. Kraaijenhagen HA (1975) Technique for parotid biopsy. J Oral Surg 33:328

    Google Scholar 

  12. Giordano M, Valentini G, Migliaresi S, Picillo U, Vatti M (1986) Different antibody patterns and different prognoses in patients with scleroderma with various extent of skin sclerosis. J Rheumatol 13:911–916

    Google Scholar 

  13. Maricq HR, Weinberger AB, LeRoy EC (1982) Early detection of scleroderma-spectrum disorders by in vivo capillary microscopy. J Rheumatol 9:289–291

    Google Scholar 

  14. Wigley FM, Wise RA, Miller R, Needleman BW, Spence RJ (1992) Anticentromere antibody as a predictor of digital ischemic loss in patients with systemic sclerosis. Arthritis Rheum 35:688–692

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Caramaschi, P., Manzo, T., Biasi, D. et al. Anticentromere antibody — clinical associations. Rheumatol Int 14, 253–255 (1995). https://doi.org/10.1007/BF00262092

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00262092

Key words

Navigation