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Intestinal iron absorption and mucosal transferrin in rats subjected to hypoxia

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Summary

Three days hypoxia (0.5 atm) increased the haemoglobin and haematocrit values in rats paralleled by enhanced intestinal iron absorption. The destination of recently-absorbed iron was primarily the erythropoietic system, viz. bone marrow, spleen and red cells. Total plasma transferrin, was increased by 30%, but no significant changes in mucosal transferrin were found. No increase in labelling of mucosal transferrin by absorbed iron was observed. These results suggest that mucosal transferrin does not play a major role in the regulation of intestinal iron absorption in hypoxia.

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Author notes

  1. Kurt R. S. Osterloh

    Present address: USA Cancer Center, University of South Alabama, Division of Haematology and Oncology, Room 414, Mobile, Alabama, USA

Authors and Affiliations

  1. Division of Clinical Cell Biology, MRC Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK

    Kurt R. S. Osterloh, R. J. Simpson, S. Snape & T. J. Peters

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  1. Kurt R. S. Osterloh
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  2. R. J. Simpson
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  3. S. Snape
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  4. T. J. Peters
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Osterloh, K.R.S., Simpson, R.J., Snape, S. et al. Intestinal iron absorption and mucosal transferrin in rats subjected to hypoxia. Blut 55, 421–431 (1987). https://doi.org/10.1007/BF00367458

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  • DOI: https://doi.org/10.1007/BF00367458

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