Abstract
The expression of the heterodimeric complex of the calcium-binding proteins MRP-8 and MRP-14 was investigated in various inflammatory dermatoses using immunohistochemical staining with the monoclonal antibody 27E10. In addition to the inflammatory infiltrate, a positive staining was repeatedly found in the involved epidermis from patients with lichen planus, lupus erythematosus and psoriasis vulgaris, but not in normal skin epidermis and/or in epidermis from leucocytoclastic vasculitis patients. The keratinocytic expression of the 27E10 antigen was dissimilar to that of the MHC class-II molecules and the adhesion molecule ICAM-1. These data indicate that the 27E10 antigen is a distinct activation marker of inflammatory keratinocytes and may have proinflammatory properties.
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Auböck J, Romani N, Grubauer G, Fritsch P (1986) HLA-DR expression on keratinocytes is a common feature of diseased skin. Br J Dermatol 14: 465–472
Berntzen HB, Fagerhol MK (1988) L1, a major granulocyte protein: Antigenic properties of its subunits. Scand J Clin Lab Invest 48: 647–652
Bos JD, De Rie MA, Meinhardi MMHM (1990) Neue Aspekte zur Pathogenese der Psoriasis. In: Macher E, Kolde G, Bröcker EB (eds) Jahrbuch der Dermatologie 1989/90. Biermann Verlag, Zülpich, pp 69–77
Czarnetzki BM, Zwadlo-Klarwasser G, Bröcker EB, Sorg C (1990) Macrophage subsets in different types of urticaria. Arch Dermatol Res 282: 93–97
Gabrielsen TO, Dale I, Brandtzaeg P, Hoel PS, Fagerhol MK, Larsen TE, Thune PO (1986) Epidermal and dermal distribution of a myelomonocytic antigen (11) shared by epithelial cells in various inflammatory skin diseases. J Am Acad Dermatol 15: 173–179
Griffiths CEM, Voorhees JJ, Nickoloff BJ (1989) Characterization of intercellular adhesion molecule-1 and HLA DR expression in normal and inflamed skin: Modulation by recombinant gamma interferon and tumor necrosis factor. J Am Acad Dermatol 20: 621–628
Hathaway GM, Traugh JA (1982) Casein kinases-multipotential protein kinases. Curr Top Cell Regul 21: 101–127
Kelly SE, Jones DB, Fleming S (1989) Calgranulin expression in inflammatory dermatoses. J Pathol 159: 17–21
Kelly SE, Hunter JAA, Jones DB, Clark BR, Fleming S (1991) Morphological evidence for calcium dependent association of calgranulin with epidermal cytoskeleton in inflammatory dermatoses. Br J Dermatol 124: 403–409
Kirkham N, Peacock SJ, Jones DB (1990) Monoclonal antibody MAC 387 recognizes a myelomonocytic antigen shared by epithelial cells in inflammatory skin diseases. Br J Dermatol 122: 61–69
Kligman D, Hilt DC (1988) The S100 protein family. TIBS 13: 437–443
Kolde G, Bröcker EB (1986) Multiple skin tumors of indeterminate cells in an adult. J Am Acad Dermatol 15: 592–597
Lange Vejlsgaard G, Ralfkiaer E, Avnstorp C, Czajkowski M, Marlin SD, Rothlein R (1989) Kinetics and characterization of intercellular adhesion molecule-1 (ICAM-1) expression on keratinocytes in various inflammatory skin lesions and malignant cutaneous lymphoma. J Am Acad Dermatol 20: 782–790
Murao S, Collart FR, Hubermann E (1989) A protein containing the cystic fibrosis antigen is an inhibitor of protein kinases. J Biol Chem 264: 8356–8360
Odink K, Cerletti N, Brüggen J, Clerc RG, Tarcsay L, Zwadlo G, Gerhards G, Schlegel R, Sorg C (1987) Two calcium binding proteins in infiltrate macrophages of rheumatoid arthritis. Nature 330: 80–82
Sams WM Jr (1980) Necrotizing vasculitis. J Am Acad Dermatol 3: 1–13
Shiohara T, Moriya N, Tanaka Y, Arai Y, Hayakawa J, Chiba M, Nagashima M (1988) Immunopathologic study of lichenoid skin diseases: Correlation between HLA-DR-positive keratinocytes or Langerhans cells and epidermotropic T cells. J Am Acad Dermatol 18: 67–74
Volc-Platzer B, Groh V, Wolff K (1987) Differential expression of class II alloantigens by keratinocytes in disease. J Invest Dermatol 89: 64–68
Von den Driesch P, Gruschwitz M, Hornstein OP, Sterry W (1992) Adhesion molecules in cutaneous vascular reactions. Arch Dermatol Res 284: 67–68
Zwadlo G, Schlegel R, Sorg C (1987) A monoclonal antibody to a subset of monocytes found only in the peripheral blood and inflammatory tissues. J Immunol 137: 512–518
Zwadlo G, Brüggen J, Gerhards G, Schlegel R, Sorg C (1988) Two calcium-binding proteins associated with specific stages of myeloid cell differentiation are expressed by subsets of macrophages in inflammatory tissues. Clin Exp Immunol 72: 510–515
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Kunz, M., Roth, J., Sorg, C. et al. Epidermal expression of the calcium binding surface antigen 27E10 in inflammatory skin diseases. Arch Dermatol Res 284, 386–390 (1992). https://doi.org/10.1007/BF00372067
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DOI: https://doi.org/10.1007/BF00372067