Summary
We have measured concentrations of ciprofloxacin in serum, hepatic tissue, gallbladder, and bile in 10 patients after a single oral dose of 750 mg given before cholecystectomy. Mean liver and gallbladder tissue concentrations were 12.76 µg·g−7±2.79 (SEM) and 5.94 µg·g−1±1.35, respectively. Concentrations in bile taken from the gallbladder (7 patients) ranged from 68 to 225 µg·ml−1, with a mean bile/serum concentration ratio of 49. Concentrations in bile taken from the common bile duct (2 patients) were 17 and 16 µg·ml−1.
References
Brogard JM, Jehl F, Monteil H, Adloff M, Blickle JF, Levy P (1985) Comparison of high-pressure liquid chromatography and microbiological assay for the determination of biliary elimination of ciprofloxacin in humans. Antimicrob Agents Chemother 28: 311–314
Chin N, Neu HC (1984) Ciprofloxacin, a quinolone carboxylic acid compound active against aerobic and anaerobic bacteria. Antimicrob Agents Chemother 25: 319–326
Wacha H, Helm EB (1982) Efficacy of antibiotics in bacterobilia. J Antimicrob Chemother 9 [Suppl A]: 131–137
Wolfson JS, Hooper DC (1985) The fluoroquinolones: Structures, mechanism of action and resistance, and spectrum of activity in-vitro. Antimicrob Agents Chemother 28: 581–586
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dan, M., Verbin, N., Gorea, A. et al. Concentrations of ciprofloxacin in human liver, gallbladder, and bile after oral administration. Eur J Clin Pharmacol 32, 217–218 (1987). https://doi.org/10.1007/BF00542200
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00542200