Summary
The light microscopic, electron microscopic and histochemical features of a highly malignant colonic tumor resected from a 39 year old man are presented. The tumor was composed predominantly of undifferentiated cells, with focally admixed neuroendocrine, exocrine and squamous cells, occasionally arranged in an organoid manner. Histochemically the tumor contained argyrophilic cells as well as cells that reacted positively with the antibodies to alpha-1-antitrypsin, alpha-1-antichymotrypsin, carcinoembryonic antigen and lysozyme. The term “stem cell carcinoma of the intestine” is proposed for this highly malignant tumor composed of undifferentiated cells exhibiting only focally their multidirectional developmental capacity.
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References
Bosman FT, Louwerens JK (1981) APUD cells in teratomas. Am J Pathol 104:174–180
Cox WF Jr, Pierce GB (1982) The endodermal origin of the endocrine cells of an adenocarcinoma of the colon of the rat. Cancer 50:1530–1538
Dictor M (1982) Ovarian malignant mixed mesodermal tumor. The occurrence of hyaline droplets containingα-antitrypsin. Human Pathol 13:930–933
Geboes K, Ray MB, Rutgeerts P, Callea F, Desmet VJ, Vantrappen G (1982) Morphological identification of alpha-1-antitrypsin in the human small intestine. Histopathology 6:55–60
Gendler SJ, Dermer GB, Silverman LM, Tokes ZA (1982) Synthesis ofα-antichymotrypsin andβ-acid glycoprotein by human breast epithelial cells. Cancer Res 42:4567–4573
Goldenberg DM, Fisher ER (1970) Histogenetic relationship between carcinoids and mucinsecreting carcinomas of colon as revealed by heterotransplantation. Br J Cancer 24:610–614
Gould VE, Memoli VA, Dardi LE (1981) Multidirectional differentiation in human epithelial cancers. J Submicrosc Cytol 13:97–115
Hamperl H (1927) Über die „gelben“ (chromaffinen) Zellen in Gesunden und kranken Magendarmschlauch. Virchows Arch [Pathol Anat] 266:509–548
Hernandez FJ, Reid JD (1969) Mixed carcinoid and mucus-secreting intestinal tumors. Arch Pathol 88:489–496
Kodama T, Fujino M, Endo Y, Obara T, Fujimoto Y, Oda T, Wada T (1980) Identification of carcinoembryonic antigen in the C-cell of the normal thyroid. Cancer 45:98–101
Lillie RO, Glenner GG (1960) Histological reaction in carcinoid tumors of the human gastrointestinal tract. Am J Pathol 36:623–652
Nieuwenhuijzen Kruseman AC, Knijnenburg G, Brutel de la Riviere G, Bosman FT (1978) Morphology and immunohistochemically-defined endocrine function of pancreatic islet cell tumors. Histopathology 2:389–399
Park CH, Reid JD (1980) Adenocarcinoma of the colon with choriocarcinoma in its metastases. Cancer 46:570–575
Pearse AGE (1969) The cytochemistry and ultrastructure of polypeptide hormone producing cells of the APUD series, and the embryologic, physiologic and pathologic implications of the concept. J Histochem Cytochem 17:303–313
Petrelli M, Tetangco E, Reid JD (1981) Carcinoma of the colon with undifferentiated, carcinoid, and squamous cell features. Am J Clin Pathol 75:581–584
Ratzenhofer M (1977) Über entarale Hyperplasien und Geschwülste der disseminierten endokrinen (parakrinen) Hellen Zellen Feyrters unter Berücksichtigung amphikriner Zellwucherungen. Verh Dtsch Ges Pathol 61:7–24
Ratzenhofer M, Auböck L (1980) The amphicrine (endo-exocrine) cells in the human gut, with a short reference to amphicrine neoplasia. Acta Morphol Acad Sci Hung 28:37–58
Ray MB, Geboes K, Callea F, Desmet VJ (1982) Alpha-1-antitrypsin immunoreactivity in gastric carcinoid. Histopathology 6:289–297
Sun TT, Shih C, Green H (1979) Keratin cytoskeletons in epithelial cells of internal organs. Proc Natl Acad Sci USA 76:2813–2816
Tahara E, Ito H, Nakagami K, Shimamoto F, Yamamoto M, Sumii K (1982a) Scirrhous argyrophil cell carcinoma of the stomach with multiple production of polypeptide hormones, amine, CEA, lysozyme, and HCG. Cancer 49:1904–1915
Tahara E, Ito H, Shimamoto F, Iwamoto T, Nakagami K, Niimoto H (1982b) Lysozyme in human gastric carcinoma: a retrospective immunohistochemical study. Histopathology 6:409–421
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Damjanov, I., Amenta, P.S. & Bosman, F.T. Undifferentiated carcinoma of the colon containing exocrine, neuroendocrine and squamous cells. Vichows Archiv A Pathol Anat 401, 57–66 (1983). https://doi.org/10.1007/BF00644789
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DOI: https://doi.org/10.1007/BF00644789