Summary
Lymphocyte subpopulations (B, T4, T8), monocytes/macrophages (LeuM5, KiM5) and HLA-DR antigen expression were studied immunohistochemically in frozen sections from 32 antral and 37 fundal biopsies of type-B chronic gastritis. Aberrant HLA-DR antigen expression in epithelial cells of gastric mucosa was found in all cases closely related to mononuclear infiltrates. Epithelial HLA-DR expression and mononuclear infiltrates were practically absent in foci of intestinal metaplasia. These findings suggest that an immunopathologic mechanism probably plays a role in initiation or perpetuation of type-B chronic gastritis.
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Papadimitriou, C.S., Ioachim-Velogianni, E.E., Tsianos, E.B. et al. Epithelial HLA-DR expression and lymphocyte subsets in gastric mucosa in type B chronic gastritis. Vichows Archiv A Pathol Anat 413, 197–204 (1988). https://doi.org/10.1007/BF00718611
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DOI: https://doi.org/10.1007/BF00718611