Abstract
We studied in humans the effect of exogenous secretin in a physiological dose on gastric acid secretion stimulated by pentagastrin and postprandial plasma gastrin concentration. Two doses of pentagastrin, 80 and 160 pmol/kg/hr were used to stimulate gastric acid secretion. Secretin in two doses, 2.8 and 5.6 pmol/kg/hr were tried to study the response on stimulated gastric acid secretion. Intravenous secretin in a dose of 5.6 pmol/kg/hr significantly inhibited the gastric acid output stimulated by intravenous pentagastrin in a dose of 160 pmol/kg/hr, from 11.25±1.5 to 5.99±1.34 meq/hr, while lower dose of intravenous secretin (2.8 pmol/kg/hr) failed to inhibit the gastric acid output stimulated by the same dose of pentagastrin. However, the lower dose of intravenous secretin (2.8 pmol/kg/hr) inhibited the gastric acid output significantly from 8.78±1.21 to 6.37±1.62 meq/hr when gastric secretion was stimulated by the lower dose of pentagastrin (80 pmol/kg/hr). The plasma concentrations of secretin during intravenous secretin in a dose of 2.8 pmol/kg/hr was similar to postprandial plasma concentrations of secretin as previously reported. Doubling the dose of intravenous secretin resulted in almost twofold higher plasma concentrations than postprandial plasma concentrations. In addition, the low dose of secretin (2.8 pmol/kg/hr) suppressed the integrated postprandial gastrin response from 13.9±3.7 to 11.2±2.8 ng/min/ml (P=0.05) when endogenous release of secretin was blocked by intravenous cimetidine. Since the dose of pentagastrin and secretin employed in this study fell in a physiologic range, the inhibitory effect of secretin on stimulated gastric acid secretion appears to be a physiologic action in humans. Contrary to the findings in dogs, the inhibitory action of secretin on gastrin release was not statistically significant but was highly suggestive.
Similar content being viewed by others
References
Chey WY, Kim MS, Lee KY, Chang T-M: Secretin is an enterogastrone in the dog. Am J Physiol 240:G239-G244, 1981
Johnson LR, Grossman MI: Secretin: The enterogastrone released by acid in the duodenum. Am J Physiol 215:885–888, 1968
Kim MS, Lee KY, Chey WY: Plasma secretin concentrations in fasting and postprandial states in dog. Am J Physiol 236:E539-E544, 1979
Tumpson DB, Johnson LR: Effect of secretin and cholecystokinin on the responses of the gastric fistula rat to pentagastrin. Proc Soc Exp Biol Med 131:186–188, 1969
Brooks AM, Grossman MI: Effect of secretin and cholecystokinin in pentagastrin-stimulated gastric secretin in man. Gastroenterology 59:114–119, 1970
Chey WY, Hitant S, Hendricks J, Lorber SH: Effect of secretin and cholecystokinin on gastric emptying and gastric secretion in man. Gastroenterology 58:820–827, 1970
Kim YC, Lee KY, Chey WY: Role of secretin on postprandial gastrin release in dog: A further study. Surgery 90:504–508, 1981
Chey WY, Lee YH, Hendricks JG, Rhodes RA, Tai HH: Secretin concentrations fasting and postprandial state in man. Am J Dig Dis 23:981–988, 1978
Schaffalitzky de Muckadell OB, Fahrenkrug J: Secretion pattern of secretin in man: Regulation by gastric acid. Gut 19:812–818, 1978
Tai HH, Chey WY: Rapid extraction of secretin from plasma by XAD-2 resin and its application in the radioimmunoassay of secretin. Anal Biochem 87:376–385, 1978
Tai HH, Chey WY: Simultaneous radioimmunoassay of secretin and gastrin. Anal Biochem 74:12–24, 1976
Snedecor GW, Cochran WG: Statistical Methods, 6th ed. Ames, Iowa, Iowa State University Press, 1967
Nakajima S, Nakamura M, Magee DF: Effect of secretin on gastric acid and pepsin secretion in response to various stimuli. Am J Physiol 216:87–91, 1969
Stening GF, Johnson LR, Grossman MI: Effects of secretin on acid and pepsin secretion in cat and dog. Gastroenterology 56:468–475, 1969
Vange M, Stening GF, Brooks FP, Grossman MI: Synthetic secretin: Comparison with natural secretin for potency and spectrum of physiological actions. Gastroenterology 55:260–267, 1968
Isenberg JI, Grossman MI, Maxwell V, Walsh JH: Increased sensitivity to stimulation of acid secretion by pentagastrin in duodenal ulcer. J Clin Invest 55:330–337, 1975
Rominger JM, Chey WY, Chang T-M: Plasma secretin concentration and gastric pH in healthy subjects and patients with digestive disease. Dig Dis Sci 26:591–597, 1981
Kleibeuker JH, Eysselsin VE, Maxwell VE, Walsh JH: Role of endogenous secretin in acid-induced inhibition of human gastric function. J Clin Invest 73:526–532, 1984
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
You, C.H., Chey, W.Y. Secretin is an enterogastrone in humans. Digest Dis Sci 32, 466–471 (1987). https://doi.org/10.1007/BF01296028
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01296028