Skip to main content
SpringerLink
Log in

Intestinal motility in irritable bowel syndrome: Is IBS a motility disorder?

Part 2. Motility of the small bowel, esophagus, stomach, and gall-ladder

  • Review Article
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Stanciu C, Bennett JR: The general pattern of gastroduodenal motility 24-hour recordings in normal subjects. Rev Med Chi Soc Med Nat Iasi 79:31–36, 1975

    Google Scholar 

  2. Vantrappen G, Janssens J, Hellemans J, Ghoos Y: The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. J Clin Invest 59:1158–1166, 1977

    Google Scholar 

  3. Thompson DG, Wingate DL, Archer L, Benson MJ, Green WJ, Hardy RJ: Normal patterns of upper small bowel motor activity recorded by prolonged radiotelemetry. Gut 21:500–506, 1980

    Google Scholar 

  4. Summers RW, Anuras S, Green J: Jejunal manometry patterns in health, partial intestinal obstruction, and pseudoobstruction. Gastroenterology 85:1290–1300, 1983

    Google Scholar 

  5. Kellow JE, Borody TJ, Phillips SF, Tucker RL, Haddad AC: Human interdigestive motility: Variations in patterns from esophagus to colon. Gastroenterology 91:386–395, 1986

    Google Scholar 

  6. Quigley EMM: Intestinal manometry—technical advances, clinical limitations. Dig Dis Sci 37:10–13, 1992

    Google Scholar 

  7. Quigley EMM: Small intestinal motor activity—its role in gut homeostasis and disease. Q J Med 65:799–810, 1987

    Google Scholar 

  8. Sarna SK: Cyclic motor activity, migrating motor complex: 1985. Gastroenterology 89:894–913, 1985

    Google Scholar 

  9. Lind CD: Motility disorders in the irritable bowel syndrome. Gastroenterol Clin North Am 20:279–295, 1991

    Google Scholar 

  10. Wingate DL: Backwards and forwards with the migrating complex. Dig Dis Sci 26:641–664, 1981

    Google Scholar 

  11. Quigley EMM, Borody TJ, Phillips SF, Wienbeck M, Tucker RL, Haddad A: Motility of the terminal ileum and ileocecal sphincter in healthy humans. Gastroenterology 87:857–866, 1984

    Google Scholar 

  12. Kingham JGC, Brown R, Colson R, Clark ML: Jejunal motility in patients with functional abdominal pain. Gut 25:375–380, 1984

    Google Scholar 

  13. Kellow JE, Miller LJ, Phillips SF, Zinsmeister AR: Dysmotility of the small intestine in irritable bowel syndrome. Gut 29:1236–1243, 1988

    Google Scholar 

  14. Kruis W, Azpiroz F, Phillips SF: Contractile patterns and transit of fluid in canine terminal ileum. Am J Physiol 249:G264-G270, 1985

    Google Scholar 

  15. Kumar D, Wingate DL: The irritable bowel syndrome: A paroxysmal motor disorder. Lancet 2:973–977, 1985

    Google Scholar 

  16. Kellow JE, Gill RC, Wingate DL: Prolonged ambulant recordings of small bowel motility demonstrate abnormalities in the irritable bowel syndrome. Gastroenterology 98:1208–1218, 1990

    Google Scholar 

  17. Lindberg G, Iwarzon M, Stal P, Seensalu R: Digital ambulatory monitoring of small bowel motility. Scand J Gastroenterol 25:216–224, 1990

    Google Scholar 

  18. Husebye E, Skar V, Aalen OO, Osnes M: Digital ambulatory manometry of the small intestine in healthy adults: Estimates of variations within and between individuals and statistical management of incomplete migrating motor complex periods. Dig Dis Sci 35:1057–1065, 1990

    Google Scholar 

  19. Dooley CP, diLorenzo C, Valenzuela JF: Variability of the migrating motor complex in the human. Dig Dis Sci 37:723–728, 1992

    Google Scholar 

  20. Quigley EMM, Donovan JP, Lane MJ, Gallagher TF: Antroduodenal manometry usefulness and limitations as an outpatient study. Dig Dis Sci 37:20–28, 1992

    Google Scholar 

  21. Code CF, Hightower NC, Morlock CG: Motility of the alimentary canal in man: Review of recent studies. Am J Med 13:328–351, 1952

    Google Scholar 

  22. Fink S: The intraluminal pressures in the intact human intestine. Gastroenterology 36:661–671, 1959

    Google Scholar 

  23. Kumar D, Wingate DL, Ruckebusch Y: Circadian variation in the propagation velocity of the migrating motor complex. Gastroenterology 91:926–930, 1986

    Google Scholar 

  24. Kerlin P, Phillips SF: Variability of motility of the ileum and jejunum in healthy humans. Gastroenterology 82:694–700, 1982

    Google Scholar 

  25. Wald A, VanThiel DH, Hoechstatter L, Gavaler JS, Egler KM, Verm R, Scott L, Lester R: Gastrointestinal transit: The effect of the menstrual cycle. Gastroenterology 80:1497–1500, 1981

    Google Scholar 

  26. Holdstock DJ, Misiewicz JJ, Waller SL: Observations on the mechanism of abdominal pain. Gut 10:19–31, 1969

    Google Scholar 

  27. Horowitz L, Farrar JT: Intraluminal small intestinal presures in normal patients and in patients with functional gastrointestinal disorders. Gastroenterology 42:455–464, 1962

    Google Scholar 

  28. Thompson DG, Laidlow SM, Wingate DL: Abnormal small-bowel motility demonstrated by radiotelemetry in a patient with irritable colon. Lancet 2:1321–1323, 1979

    Google Scholar 

  29. Borody T, Byrnes D, Bell D, Henderson L: The migrating motor complex—its relation to circulating CCK, motilin and pancreatic polypeptide in irritable bowel patients and in controls. Clin Res 32:23A, 1984

    Google Scholar 

  30. Kellow JE, Phillips SF: Altered small bowel motility in irritable bowel syndrome is correlated with symptoms. Gastroenterology 92:1885–1893, 1987

    Google Scholar 

  31. Phillips SF, Quigley EMM, Kumar D, Kamath PS: Motility of the ileocolonic junction. Gut 29:390–406, 1988

    Google Scholar 

  32. Houghton LA, Read NW, Heddle R, Maddern GJ, Downton J, Toouli J, Dent J: Motor activity of the gastric antrum, pylorus and duodenum under fasted conditions and after a liquid meal. Gastroenterology 94:1276–1284, 1988

    Google Scholar 

  33. Heddle R, Dent J, Toouli J, Read NW: Topography and measurement of pyloric pressure waves and tone in humans. Am J Physiol 255:G490-G497, 1988

    Google Scholar 

  34. Quigley EMM: Antroduodenal manometry.In Problems in General Surgery: Tests of Foregut Function. RA Hinder (ed). Philadelphia, JB Lippincott, 1992, pp. 152–171

    Google Scholar 

  35. Summers RW, Anuras S, Green J: Jejunal manometry patterns in health, intestinal obstruction and pseudoobstruction. Gastroenterology 85:1290–1300, 1983

    Google Scholar 

  36. Stanghellini V, Camilleri M, Malagelada J-R: Chronic idiopathic intestinal pseudo-obstruction: Clinical and intestinal manometric findings. Gut 28:5–12, 1987

    Google Scholar 

  37. Malagelada J-R, Camilleri M, Stanghellini V: Manometric Diagnosis of Gastrointestinal Motility Disorders. New York, Thieme, 1986

    Google Scholar 

  38. Quigley EMM, Phillips SF, Dent J: Distinctive patterns of interdigestive motility at the canine ileocolonic junction. Gastroenterology 87:836–844, 1984

    Google Scholar 

  39. Sarna SK: Giant migrating contractions and their myoelectric correlates in the small intestine. Am J Physiol 253:G697-G705, 1987

    Google Scholar 

  40. Otterson MF, Sarna SK, Moulder JE: Effects of fractionated doses of ionizing radiation on small intestinal motor activity. Gastroenterology 95:1249–1257, 1988

    Google Scholar 

  41. Kamath PS, Hoepfner MT, Phillips SF: Short-chain fatty acids stimulate motility of the canine ileum. Am J Physiol 253:G427-G433, 1987

    Google Scholar 

  42. Kruis WA, Azpiroz F, Phillips SF: Contractile patterns and transit of fluid in canine terminal ileum. Am J Physiol 249:G264-G270, 1985

    Google Scholar 

  43. Quigley EMM, Lof J, Johnson TJ, Jacobs DL, Mandel KG: Modification by mebeverine of volatile fatty acid-induced terminal ileal motor patterns. Gastroenterology 99:A1227, 1990

    Google Scholar 

  44. Martin L: Observations on small intestinal hypomotility and states of hypertonicity arising from functional basis. Am J Med 8:196–205, 1950

    Google Scholar 

  45. Roth HP, Ferreri RN, Petti MA, Evans MW: Motility of the small intestine during emotional reactions. Ann Intern Med 38:38–52, 1953

    Google Scholar 

  46. Weeks DM: Observations of small and large bowel motility in man. Gastroenterology 6:185–190, 1946

    Google Scholar 

  47. McRae S, Younger K, Thompson DG, Wingate DL: Sustained mental stress alters human jejunal motor activity. Gut 23:404–409, 1982

    Google Scholar 

  48. Valori RM, Wingate DL: Stress, distress and the fasting motor complex (MC). Gastroenterology 84:1340A, 1983

    Google Scholar 

  49. Valori RM, Kumar D, Wingate DL: Effects of different types of stress and of “prokinetic” drugs on the control of the fasting motor complex in humans. Gastroenterology 90:1890–1900, 1986

    Google Scholar 

  50. Stanghellini V, Malagelada JR, Zinsmeister AR, Go VLW, Kao PC: Stress-induced gastroduodenal motor disturbances in humans: Possible humoral mechanisms. Gastroenterology 85:83–91, 1983

    Google Scholar 

  51. Corbett CL, Thomas S, Read NW, Hobson N, Bergman I, Holdsworth CD: Electrochemical detection for breath hydrogen determination: Measurement of small bowel transit time in normal subjects and patients with the irritable bowel syndrome. Gut 22:836–840, 1981

    Google Scholar 

  52. Cann PA, Read NW, Brown C, Hobson N, Holdsworth CD: Irritable bowel syndrome: Relationship of disorders in the transit of a single solid meal to symptom patterns. Gut 24:405–411, 1983

    Google Scholar 

  53. Thompson DG: The clinical application of exhaled breath hydrogen testing for the study of gastrointestinal motility.In Gastrointestinal Motility, Which Test? NW Read (ed). Petersfield, England, Wrightson Biomedical Publishing, 1989, pp 143–147

    Google Scholar 

  54. Nielsen OH, Gjorup T, Christensen FN: Gastric emptying rate and small bowel transit time in patients with irritable bowel syndrome determined with99mTc-labeled pellets and scintigraphs. Dig Dis Sci 31:1287–1291, 1986

    Google Scholar 

  55. Jian R, Vigneron N, Najean Y, Bernier JJ: Gastric emptying and intragastric distribution of lipids in man. A new scintigraphic method of study. Dig Dis Sci 27:705–711, 1982

    Google Scholar 

  56. Jian R, Najean Y, Bernier JJ: Measurement of intestinal progression of a meal and its residues in normal subjects and patients with functional diarrhea by a dual isotope technique. Gut 25:728–731, 1984

    Google Scholar 

  57. Trotman IF, Price CC: Bloated irritable bowel syndrome defined by dynamic99mTc bran scan. Lancet 2:364–366, 1986

    Google Scholar 

  58. Watson WC, Sullivan N, Corke M, Rush D: Incidence of oesophageal symptoms in patients with irritable bowel syndromes. Gut 17:827A, 1976

    Google Scholar 

  59. Stark GA, McMahon TP, Richter JE: Increasing evidence for the irritable gut syndrome. Gastroenterology 92:1652A, 1987

    Google Scholar 

  60. Whorwell PJ, Clouter C, Smith CL: Oesophageal motility in the irritable bowel syndrome. Br Med J 282:1101–1102, 1981

    Google Scholar 

  61. McMahon TP, Richter JE: Non-cardiac chest pain (NCCP) and irritable bowel syndrome (IBS): Part of a continuum? Gastroenterology 90:1546A, 1986

    Google Scholar 

  62. Soffer EE, Scalabrini P, Pope CE, Wingate DL: Effect of stress on oesophageal motor function in normal subjects and in patients with the irritable bowel syndrome. Gut 29:1591–1594, 1988

    Google Scholar 

  63. Clouse RE, Eckert TC: Gastrointestinal symptoms of patients with esophageal contraction abnormalities. Dig Dis Sci 31:236–240, 1986

    Google Scholar 

  64. Ayres RC, Robertson DA, Naylor K, Smith Cl: Stress and oesophageal motility in normal subjects and patients with irritable bowel syndrome. Gut 30:1540–1543, 1989

    Google Scholar 

  65. Barish CF, Castell DO, Richter JE: Graded esophageal balloon distension: A new provocative test for noncardiac chest pain. Dig Dis Sci 31:1292–1298, 1986

    Google Scholar 

  66. Anderson KO, Dalton CB, Bradley LA, Richter JE: Stress induces alteration of esophageal pressures in healthy volunteers and noncardiac chest pain patients. Dig Dis Sci 34:83–91, 1989

    Google Scholar 

  67. Richter JE, Barish CF, Castell DO: Abnormal sensory perception in patients with esophageal chest pain. Gastroenterology 91:845–851, 1986

    Google Scholar 

  68. Clouse RE, Staiano A, Landau DW, Schlacter JL: Manometric findings during spontaneous chest pain with presumed esophageal “spasms”. Gastroenterology 85:395–402, 1983

    Google Scholar 

  69. Castell DO: Ambulatory monitoring in esophageal disease. Viewpoints Dig Dis 21:1–4, 1989

    Google Scholar 

  70. Richter JE, Hackshaw BT, Wu WC, Castell DO: Edrophonium: A useful provocative test for esophageal chest pain. Ann Intern Med 102:14–21, 1985

    Google Scholar 

  71. Perkel MS, Moore C, Hersch T, Cavidson ED: Metoclopramide therapy in patients with delayed gastric emptying. Dig Dis Sci 24:662–666, 1979

    Google Scholar 

  72. You CH, Lee KY, Chey WY, Menguy R: Electrogastrographic study of patients with unexplained nausea, bloating and vomiting. Gastroenterology 79:311–314, 1980

    Google Scholar 

  73. Rees WDW, Miller LJ, Malagelda JR: Dyspepsia, antral motor dysfunction, and gastric stasis of solids. Gastroenterology 78:360–365, 1980

    Google Scholar 

  74. Milo R: Use of the peripheral dopamine antagonist domperidone, in management of gastrointestinal symptoms in patients with irritable bowel syndrome. Curr Med Res Opin 6:577–584, 1980

    Google Scholar 

  75. Fielding JF: The irritable bowel syndrome. Clin Gastroenterol 6:607–622, 1977

    Google Scholar 

  76. Acharya U, Waite N, Howlett P, Tanner AR, Smith CL: Failure to demonstrate altered gastric emptying in irritable bowel syndrome. Dig Dis Sci 28:889–892, 1983

    Google Scholar 

  77. Lennard-Jones JE: Functional gastrointestinal disorders. N Engl J Med 308:431–435, 1983

    Google Scholar 

  78. Colin-Jones DG, Bloom B, Bodemar G, Crean G, Freston J, Gugler R, Malagelada JR, Nyren O, Petersen H, Piper D: Management of dyspepsia: Report of a working party. Lancet 1:576–579, 1988

    Google Scholar 

  79. Talley NJ, Phillips SF: Non-ulcer dyspepsia: Potential causes and pathophysiology. Ann Intern Med 108:865–879, 1988

    Google Scholar 

  80. Jian R, Durcot F, Piedeloup C, Mary JY, Najean Y, Bernier JJ: Measurement of gastric emptying in dyspeptic patients: Effect of a new gastrokinetic agent (cisapride). Gut 26:352–358, 1985

    Google Scholar 

  81. Geldof H, Vanderschee EJ, Van Blankenstein M, Grashuis JL: Electrogastrographic study of gastric myoelectrical activity in patients with unexplained nausea and vomiting. Gut 27:799–808, 1986

    Google Scholar 

  82. Cottrell CR, Sninsky CA, Martin JL, Mathias JR: Are alterations in gastroduodenal motility responsible for previously unexplained nausea, vomiting, and abdominal pain? Dig Dis Sci 27:650A, 1982

    Google Scholar 

  83. Malagelada JR, Stanghellini V: Manometric evaluation of functional upper gut symptoms. Gastroenterology 88:1223–1231, 1985

    Google Scholar 

  84. Labo G, Bortolotti M, Vezzadini P, Bonora G, Bensani G: Interdigestive gastroduodenal motility and serum motilin levels in patients with idiopathic delay in gastric emptying. Gastroenterology 90:20–26, 1986

    Google Scholar 

  85. Kerlin P: Post-prandial antral hypomotility in patients with iodiopathic nausea and vomiting. Gut 30:54–59, 1989

    Google Scholar 

  86. Corinaldesi R, Stanghellini V, Raiti C, Rea E, Salgemini R, Barbara L: Effect of chronic administration of cisapride on gastric emptying of a solid meal and on dyspeptic symptoms in patients with idiopathic gastroparesis. Gut 28:300–305, 1987

    Google Scholar 

  87. Keshavarzian A, Anagnostides A, Chadwick VS: Gallbladder function in the irritable bowel syndrome. J Clin Gastroenterol 9:366, 1987

    Google Scholar 

  88. Misra SP, Dwivedi M, Mital M, Misra V: Gallbladder dynamics in patients with irritable bowel syndrome and essential dyspepsia. J Clin Gastroenterol 13:65–68, 1991

    Google Scholar 

  89. Braverman DZ: Gallbladder contraction in patients with irritable bowel syndrome. Isr J Med Sci 23:181–184, 1987

    Google Scholar 

  90. Kellow JE, Miller LJ, Phillips SF, Zinsmeister AR, Charboneau JW: Altered sensitivity of the gallbladder to cholecystokinin octapeptide in irritable bowel syndrome. Am J Physiol 253:G650-G655, 1987

    Google Scholar 

  91. Kamath PS, Gaisano HY, Phillips SF, Miller LJ, Charboneau JW, Brown ML, Zinsmeister AR: Abnormal gallbladder motility in irritable bowel syndrome: Evidence for target-organ defect. Am J Physiol 260:G815-G819, 1991

    Google Scholar 

  92. Sarna SK: Motor correlates of functional gastrointestinal symptoms. Viewpoints Dig Dis 20:1–4, 1988

    Google Scholar 

  93. Wingate DL: The brain-gut link. Viewpoints Dig Dis 17:17–20, 1985

    Google Scholar 

  94. Bueno L: Stress and upper gut motility disorders: Mechanisms involved.In Non-Ulcer Dyspepsia: Pathophysiological and Therapeutic Approaches. J-P Galmiche, R Jian, M Mignon, PH Roszniewski (eds). Paris, John Libbey Eurotext, 1991, pp 59–66

    Google Scholar 

  95. Bockus HL, Bank J, Wilkinson SA: Neurogenic mucous colitis. Am J Med Sci 176:813–829, 1928

    Google Scholar 

  96. Smart HL, Atkinson M: Abnormal vagal function in irritable bowel syndrome. Lancet 2:475–478, 1987

    Google Scholar 

  97. McAllister C, McGrath F, Fielding JF: Altered skin temperature and electromyographic activity in the irritable bowel syndrome. Biomed Pharmacother 44:399–401, 1990

    Google Scholar 

  98. Debas HT, Mulvihill SJ: Neuroendocrine design of the gut. Am J Surg 161:243–249, 1991

    Google Scholar 

  99. Maxton DG, Whorwell PJ: Functional bowel symptoms in diabetes—the role of autonomic neuropathy. Postgrad Med J 67:991–993, 1991

    Google Scholar 

  100. Mayer EA, Raybould HE: Role of visceral afferent mechanisms in functional bowel disorders. Gastroenterology 99:1688–1704

  101. Klein KB: Controlled treatment trials in the irritable bowel syndrome: A critique. Gastroenterology 85:232–241, 1988

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Section of Digestive Diseases and Nutrition, Department of Internal Medicine, University of Nebraska Medical Center, 600 South 42nd Street, 68198-2000, Omaha, Nebraska

    Daniel P. McKee MD &  Eamonn M. M. Quigley MD, FRCP Glasg

Authors
  1. Daniel P. McKee MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eamonn M. M. Quigley MD, FRCP Glasg
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

McKee, D.P., Quigley, E.M.M. Intestinal motility in irritable bowel syndrome: Is IBS a motility disorder?. Digest Dis Sci 38, 1773–1782 (1993). https://doi.org/10.1007/BF01296098

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01296098

Keywords

Search

Navigation