Abstract
Twenty-one adult outpatients with dyspepsia and endoscopically proven duodenitis without chronic ulceration completed a double-blind trial of either cimetidine (1 g/day) or placebo. Treatment with cimetidine for 6 weeks resulted in a significant improvement in symptoms and in the endoscopic appearance of the duodenitis when compared to treatment with placebo. The symptomatic and endoscopic inprovement, however, was not associated with any significant change in the histological grading of the duodenitis.
Similar content being viewed by others
References
Cotton PB, Price AB, Tighe DR, Beales SJM: Preliminary evaluation of “duodenitis” by endoscopy and biopsy. Br Med J 3:430–433, 1973
Gelzayd EA, Biederman MA, Gelfand DW: Changing concepts of duodenitis. Am J Gastroenterol 64:213–216, 1975
Gregg JA, Gerebedian M: Duodenitis. Am J Gastroenterol 61:177–184, 1974
Thomson WO, Joffe SN, Robertson AG, Less FD, Imrie CW: Is duodenitis a dyspeptic myth? Lancet 2:177–184, 1977
Blackwood WS, Mandgal DP, Pickard RG, Lawrence D, Northfield TC: Cimetidine in severe duodenal ulceration. Lancet 2:174–176, 1976
Gray GR, Smith IS, McKenzie I, Cream GP, Gillespie G: Oral cimetidine in severe duodenal ulceration. Lancet 1:4–7, 1977
Stephen JB, Lesna M, Venables CW: Endoscopic appearances and histological changen in ulcer-associated duodenitis. Br J Surg 65:438–441, 1978
Whitehead R, Roca M, Meikle DD, Skinner J, Truelove SC: The histological classification of duodenitis in fibreoptic biopsy specimens. Digestion 13:129–136, 1975
Whitehead R, Piris J: Morphological aspects of non-ulcer dyspepsia.In Cimetidine, C Wastell, P Lance (eds) Edinburgh, Churchill Livingstone, 1978, pp 111–124
La Brooy S, Lovell D, Misiewicz JJ: The treatment of nonulcer dyspepsia.In Cimetidine, C Wastell, P Lance (eds). Edinburgh, Churchill Livingstone, 1978, pp 131–137
Gilmore HM, Forrest JAH, Fettes M, Logan RFA, Heading RC: The effect of cimetidine on duodenitis.In Cimetidine, C Wastell, P Lance (eds). Edinburgh, Churchill Livingstone, 1978, pp 141–146
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mackinnon, M., Willing, R.L. & Whitehead, R. Cimetidine in the management of symptomatic patients with duodenitis. Digest Dis Sci 27, 217–219 (1982). https://doi.org/10.1007/BF01296918
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01296918