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Rodent models for carcinoma of the colon

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Conclusion

Rodent models for colon cancer have contributed information on many aspects of the disease that may be applicable to prevention and treatment. Data of major importance on factors that retard or enhance tumorigenesis are now within reach. There are several basic research needs in the further development of animal models. Major questions, such as the controversies over the role of dietary fat and fiber, will be resolved only if investigators use comparable, consistent regimens and protocols, report full results, and use comparable endpoint and statistical analyses. If the deceptively simple controversies in the animal models can be resolved, we shall have powerful tools for further investigation of carcinogenesis in the intestine.

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Authors and Affiliations

  1. Department of Nutrition and Food Science, Massachusetts Institute of Technology, 50 Ames Street, Building E18-615, 02139, Cambridge, Massachusetts

    Adrianne E. Rogers MD & Kathleen M. Nauss PhD

Authors
  1. Adrianne E. Rogers MD
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  2. Kathleen M. Nauss PhD
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Supported in part by grants from the NCI: R01 CA25538 and R01 CA26917

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Rogers, A.E., Nauss, K.M. Rodent models for carcinoma of the colon. Digest Dis Sci 30, 87S–102S (1985). https://doi.org/10.1007/BF01296986

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  • DOI: https://doi.org/10.1007/BF01296986

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