References
Barnes PJ: Asthma as an axon reflex. Lancet i:242–245, 1986
Langley JN: The autonomic nervous system. London, Heffner, 1921
Furness JB, Costa M: Types of nerves in the enteric nervous system. Neuroscience 5:1–20, 1980
Gabella G: Structure of the autonomic nervous system. London, Chapman & Hall, 1976
Agostoni E, Chinnok JE, De Burg Daly M, Murray JG: Functional and histological studies to the heart, lungs and abdominal viscera in the cat. J Physiol 135:182–205, 1956
Kuo DC, Yang GCH, Yamasaki DS, Krauthamer GH: A wide-field electron microscopic analysis of the fiber constituents of the major splanchnic nerve in the cat. J Comp Neurol 210:49–58, 1982
Dogiel AS: Zur Frage über die Ganglien der Darmgeflechte bei den Säugtierern. Anat Anz 10:517–528, 1895
Dogiel AS: Uber den Bau der Ganglien in den Geflachten des Darmes und der Gallenblase den Menschen und der Saugetiere. Arch Anat Physiol Leipzig Anat Abt, 130–158, 1899
Sjöqvist A, Fahrenkrug J, Jodal M, Lundgren O: Effect of apamin on release of vasoactive intestinal polypeptide (VIP) from cat intestines. Acta Physiol Scand 119:69–76, 1983
Burnstock G: The purinergic nervous system. Pharmacol Rev 24:509–581, 1972
Schultzberg M, Hökfelt T, Nilsson G, Terenius L, Rehfeld JF, Brown M, Elde R, Goldstein M, Said S: Distribution of peptide and catecholamine-containing neurons in the gastrointestinal tract of the rat and the guinea pig: Immunohistochemical studies with antisera to substance P, vasoactive intestinal polypeptide, enkephalins, somatostatin, gastrin/cholecystokinin, neurotensin and dopamine beta-hydroxylase. Neuroscience 5:689–744, 1980
Keast JR, Furness JB, Costa M: Distribution of certain peptide-containing nerve fibers and endocrine cells in the gastrointestinal mucosa in five mammalian species. J Comp Neurol 236:403–422, 1985
Furness JB, Costa M, Gibbins IJ, Llewellyn-Smith IJ, Oliver JR: Neurochemically similar myenteric and submucous neurons directly traced to the mucosa of the small intestine. Cell Tissue Res 241:155–163, 1985
Lundberg JM: Evidence for coexistence of vasoactive intestinal polypeptide (VIP) and acetylcholine in neurons of cat exocrine glands. Acta Physiol Scand (suppl 496):1–57, 1981
Hirst GDS: Mechanisms of peristalsis. Br Med Bull 35:263–268, 1979
North RA: Electrophysiology of the enteric nervous system. Neuroscience 7:315–325, 1982
Wood JD: Physiology of the enteric nervous system.In Physiology of the Gastrointestinal Tract, Vol 1, 2nd ed. LR Johnson (ed). New York, Raven Press, 1987, pp 67–109
Brookes SJH, Ewart WR, Wingate DL: Intracellular recordings from myenteric neurons in the human colon. J Physiol 390:305–318, 1987
Wood JD: Enteric neurophysiology. Am J Physiol 247:G585-G598, 1984
North RA, Surprenant A: Inhibitory synaptic potentials resulting fromα-adrenoreceptor activation in guinea-pig submucous plexus neurones. J Physiol 358:17–33, 1985
Hodgkiss JP, Lees GM: Morphological studies of electrophysiologically identified myenteric plexus neurons of the guinea-pig ileum. Neuroscience 8:593–608, 1983
Bornstein JC, Costa M, Furness JB, Lees GM: Electrophysiology and enkephalin immunoreactivity of identified myenteric plexus neurones of guinea-pig small intestine. J Physiol 351:313–325, 1984
Katayama Y, Lees GM, Pearson GT: Electrophysiology and morphology of vasoactive-intestinal-peptide-immuno-reactive neurones of the guinea-pig ileum. J Physiol 378:1–11, 1986
Bornstein JC, Costa M, Furness JB: Synaptic inputs to immunohistochemically identified neurones in the submucous plexus of the guinea-pig small intestine. J Physiol 381:465–482, 1986
Bornstein JC, Furness JB, Costa M: Sources of excitatory synaptic inputs to neurochemically identified submucous neurons of guinea-pig small intestine. J Auton Nerv Syst 18:83–91, 1987
Hubel KA: Intestinal nerves and ion transport: Stimuli, reflexes and responses. Am J Physiol 248:G261-G271, 1985
Cooke HJ: Neurobiology of the intestinal mucosa. Gastroenterology 90:1057–1081, 1986
Cooke HJ: Neural and humoral regulation of small intestinal electrolyte transport.In Physiology of the Gastrointestinal Tract, Vol 2, 2nd ed, LR Johnson (ed). New York, Raven Press, 1987, pp 1307–1350
Lundgren O: Microcirculation of the gastrointestinal tract and pancreas.In Handbook of Physiology, Section 2, Vol IV, EM Renkin, CC Michel (eds). Bethesda, Maryland, American Physiological Society, 1984, pp 799–863
Biber B, Lundgren O, Svanvik J: Studies on the intestinal vasodilatation observed after mechanical stimulation of the mucosa of the gut. Acta Physiol Scand 82:177–190, 1971
Biber B, Fara J, Lundgren O: A pharmacological study of intestinal vasodilator mechanisms in the cat. Acta Physiol Scand 90:673–683, 1974
Biber B, Fara J, Lundgren O: Intestinal vasodilatation in response to transmural electrical field stimulation. Acta Physiol Scand 87:277–282, 1973
Jodal M, Lundgren O, Sjöqvist A: The effect of apamin on non-adrenergic, non-cholinergic vasodilator mechanisms in the intestines in the cat. J Physiol 338:207–219, 1983
Sjöqvist A, Fahrenkrug J, Jodal M, Lundgren O: Effect of apamin on release of vasoactive intestinal polypeptide (VIP) from cat intestines. Acta Physiol Scand 119:69–76, 1983
Beubler E, Juan H: PGE-release, blood flow and transmucosal water movement after mechanical stimulation of the rat jejunal mucosa. Naunyn-Schmiedeberg's Arch Pharmacol 305:91–95, 1978
Fasth S, Hultén L, Lundgren O, Nordgren S: Vascular responses to mechanical stimulation of the mucosa of the cat colon. Acta Physiol Scand 101:98–104, 1977
Fioramonti J, Bueno L: Relation between intestinal motility and mesenteric blood flow in the conscious dog. Am J Physiol 246:G108-G113, 1984
Biber B: Vasodilator mechanisms in the small intestine. Acta Physiol Scand (suppl 401):1–31, 1973
Rozsa Z, Jancso G, Varro V: Possible involvement of capsaicin sensitive sensory nerves in the regulation of intestinal blood flow in the dog. Naunyn-Schmiedeberg's Arch Pharmacol 326:352–356, 1984
Rozsa Z, Varro A, Jancso G: Use of immunoblockade to study the involvement of peptidergic afferent nerves in the intestinal vasodilatory response to capsaicin in the dog. Eur J Pharmacol 115:59–64, 1985
Rozsa Z, Sharkey KA, Varro V: Evidence for a role of capsaicin-sensitive mucosal afferent nerves in the regulation of mesenteric blood flow in the dog. Gastroenterology 90:906–910, 1986
North RA: Electrophysiology of the enteric nervous system. Neuroscience 7:315–325, 1982
Hirst GDS, McKirdy HC: A nervous mechanism for descending inhibition in guinea-pig small intestine. J Physiol 238:129–144 1974
Hirst GDS, Holman ME, McKirdy HC: Two descending nerve pathways activated by distension of guinea-pig small intestine. J Physiol 244:113–127, 1975
Makhlouf GM: Enteric neuropeptides: Role in neuromuscular activity of the gut. Trends in Pharmacol Sci 6:214–218, 1985
Furness JB, Costa M: The Enteric Nervous System. New York, Churchill Livingstone, 1987
Grider JR, Makhlouf GM: Colonic peristaltic reflex: Identification of vasoactive intestinal peptide as mediator of descending relaxation. Am J Physiol 251:G40-G45, 1986
Sjöqvist A, Fahrenkrug J: Release of vasoactive intestinal polypeptide anally of a local distension of the feline small intestine. Acta Physiol Scand 130:433–438, 1987
Bywater RAR, Taylor GS: Non-cholinergic excitatory and inhibitory junction potentials in the circular smooth muscle of the guinea-pig ileum. J Physiol 374:153–164, 1986
Tonini M, Frigo G, Lecchini S, D'Angelo L, Crema A: Hyoscine-resistant peristalsis in guinea-pig ileum. Eur J Pharmacol 71:375–381, 1981
Costa M, Furness JB, Pullin CO, Bornstein J: Substance P enteric neurons mediate non-cholinergic transmission to the circular muscle of the guinea-pig intestine. Naunyn-Schmiedeberg's Arch Pharmacol 328:446–453, 1985
Franco R, Costa M, Furness JB: Evidence for the release of endogenous substance P from intestinal nerves. Naunyn-Schmiedeberg's Arch Pharmacol 306:195–201, 1979
Björkroth U: Inhibition of smooth muscle contractions induced by capsaicin and electrical transmural stimulation by a substance P antagonist. Acta Physiol Scand (suppl 515):11–16, 1983
Donnerer J, Holzer P, Lembeck F: Release of dynorphin, somatostatin and substance P from the vascularly perfused small intestine of the guinea-pig during peristalsis. Br J Pharmacol 83:919–925, 1984
Yokoyama S, North RA: Electrical activity of longitudinal and circular muscle during peristalsis. Am J Physiol 244:G83-G88, 1983
Field M, McColl I: Ion transport in rabbit ileal mucosa. III: Effects of catecholamines. Am J Physiol 225:852–857, 1973
Sjövall H, Redfors S, Hallbäck D-A, Eklund S, Jodal M, Lundgren O: The effect of splanchnic nerve stimulation on blood flow distribution, villous tissue osmolality and fluid and electrolyte transport in the small intestine of the cat. Acta Physiol Scand 117:359–365, 1983
Hubel KA: The effects of electrical field stimulation and tetrodotoxin on ion transport by the isolated rabbit ileum. J Clin Invest 62:1039–1047, 1978
Hubel KA, Callanan D: Effects of Ca2+ on ileal transport and electrically induced secretion. Am J Physiol 239:G18-G22, 1980
Cooke HJ, Shonnard K, Wood JD: Effects of neuronal stimulation on mucosal transport in guinea pig ileum. Am J Physiol 245:G290-G296, 1983
Cooke HJ, Nemeth PR, Wood JD: Histamine action on guinea pig ileal mucosa. Am J Physiol 246:G372-G377, 1984
Hubel KA, Shirazi S: Human ileal ion transportin vitro: Changes with electrical field stimulation and tetrodotoxin. Gastroenterology 83:63–68, 1982
Hubel KA: The effects of scorpion venom on electrolyte transport by rabbit ileum. Am J Physiol 244:G501-G506, 1983
Carey HV, Cooke HJ, Zafirova M: Mucosal responses evoked by stimulation of ganglionic cell somas in the submucosal plexus of the guinea-pig ileum. J Physiol 364:69–79, 1985
Andres H, Bock R, Bridges RJ, Rummel W, Schreiner J: Submucosal plexus and electrolyte transport across rat colonic mucosa. J Physiol 364:301–312, 1985
Bridges RJ, Rack M, Rummel W, Schreiner J: Mucosal plexus and electrolyte transport across the rat colonic mucosa. J Physiol 376:531–542, 1986
Caren JF, Meyer JH, Grossman MI: Canine intestinal secretion during and after rapid distension of the small bowel. Am J Physiol 227:183–188, 1974
Sjövall H, Brunsson I, Jodal M, Lundgren O: The effect of vagal nerve activation on net fluid transport in the jejunum of the cat. Acta Physiol Scand 117:351–357, 1983
Sjövall H, Redfors S, Jodal M, Lundgren O: On the mode of action of the sympathetic fibres on intestinal fluid transport: Evidence for the existence of a glucose stimulated secretory nervous pathway in the intestinal wall. Acta Physiol Scand 119:39–48, 1983
Sjövall H, Jodal M, Lundgren O: Further evidence for a glucose-activated secretory mechanism in the jejunum of the cat. Acta Physiol Scand 120:437–443, 1984
Sjövall H: Evidence for separate sympathetic regulation of fluid absorption and blood flow in the feline jejunum. Am J Physiol 247:G510-G514, 1984
Eklund S, Cassuto J, Jodal M, Lundgren O: The involvement of the enteric nervous system in the intestinal secretion evoked by cyclic adenosine 3′,5′-monophosphate. Acta Physiol Scand 120:311–316, 1984
Eklund S, Jodal M, Lundgren O: The net fluid secretion caused by cyclic 3′,5′-guanosine monophosphate in the rat jejunumin vivo is mediated by a local nervous reflex. Acta Physiol Scand 128:57–63, 1986
Eklund S, Jodal M, Lundgren O: The enteric nervous system participates in the secretory response to the heat stable enterotoxins ofEscherichia coli in rats and cats. Neuroscience 14:673–681, 1985
Taylor AE, Wright EM, Schultz SG, Curran PF: Effects of sugars on ion fluxes in intestine. Am J Physiol 214:836–842, 1968
Sjövall H, Jodal M, Lundgren O: Sympathetic control of intestinal fluid and electrolyte transport. News in Physiol Sci 2:214–217, 1987
Binder HJ, Lemp GF, Gardner JD: Receptors for vasoactive intestinal peptide and secretin on small intestinal epithelial cells. Am J Physiol 238:G190-G196, 1980
Gaginella TS, Rimele TJ, Wietecha M: Studies on rat intestinal epithelial cell receptors for serotonin and opiates. J Physiol 335:101–111, 1983
Gaginella TS: Neuroregulation of intestinal ion transport. Trends in Pharmacological Sciences 5:397–399, 1984
Zimmerman TW, Binder HJ: Muscarinic receptors on rat isolated colonic epithelial cells. A correlation between inhibition of [3H]Quinuclidinyl benzilate binding and alteration in ion transport. Gastroenterology 83:1244–1251, 1982
Cooke HJ: Influence of enteric cholinergic neurons on mucosal transport in guinea pig ileum. Am J Physiol 246:G263-G267, 1984
Perdue MH, Galbraith R, Davison JS: Evidence for substance P as a functional neurotransmitter in guinea pig intestinal mucosa. Regulatory Peptides 18:63–74, 1987
Hubel KA: Neuronal regulation of ion transport.In Intestinal Absorption and Secretion. Falk Symposium. E Skadhauge, K Heintze (eds). Lancaster, England, MTP Press, 1984, pp. 67–82
Said S: Vasoactive Intestinal Peptide. New York, Raven Press, 1982
Cassuto J, Jodal M, Tuttle R, Lundgren O: On the role of intramural nerves in the pathogenesis of cholera toxininduced intestinal secretion. Scand J Gastroenterol 16:377–384, 1981
Eklund S, Sjöqvist A, Fahrenkrug J, Jodal M, Lundgren O: Somatostatin and methionine-enkephalin inhibit cholera toxin induced jejunal net fluid secretion and release of vasoactive intestinal polypeptide in the catin vivo. Acta Physical Scand 133:551–557, 1988
Brunsson I, Fahrenkrug J, Jodal M, Sjöqvist A, Theodorsson-Norheim E, Lundgren O: On the role of vasoactive intestinal polypeptide, tachykinins and opioids in the secretory reflex elicited by peritonitis in the cat small intestine. Acta Physiol Scand 1988 (submitted)
Gaginella TS, O'Dorisio TM, Hubel KA: Release of vasoactive intestinal polypeptide by electrical field stimulation of rabbit ileum. Regul Peptides 2:165–174, 1981
Cooke HJ, Zafirova M, Carey HV, Walsh JH, Grider J: Vasoactive intestinal polypeptide actions on the guinea pig intestinal mucosa during neural stimulation. Gastroenterology 92:361–370, 1987
Iggo A: Gastrointestinal tension receptors with unmyelinated afferent fibers in the vagus of the cat. Q J Exp Physiol 42:130–143, 1957
Paintal AS: Responses from mucosal mechanoreceptors in the small intestine of the cat. J Physiol 139:353–368, 1957
Cassuto J, Jodal M, Sjövall H, Lundgren O: Nervous control of intestinal secretion. Clin Res Rev 1(suppl 1):11–21, 1981
Lundberg JM, Dahlström A, Bylock A, Ahlman H, Pettersson G, Larsson I, Hansson H-A, Kewenter J: Ultrastructural evidence for an innervation of epithelial enterochromaffin cells in the guinea pig duodenum. Acta Physiol Scand 104:3–12, 1978
Cassuto J, Jodal M, Lundgren O: The effect of nicotinic and muscarinic receptor blockade on cholera toxin induced intestinal secretion in rats and cats. Acta Physiol Scand 114:573–577, 1982
Eklund S, Fahrenkrug J, Jodal M, Lundgren O, Sjöqvist A: Mechanisms of neurotensin-induced fluid secretion in the cat ileumin vivo. Acta Physiol Scand 129:203–211, 1987
Rökeaus Å: Neurotensin increases net fluid secretion in the small rat intestine and its modulation by nervous blockade. Dig Dis Sci 29:71S, 1984
Weems WA, Seidel ER, Johnson LR: Inductionin vitro of a specific pattern of jejunal propulsive behavior by cholecystokinin. Am J Physiol 248(supp1):G470-G478, 1985
Barber DL, Buchan AMJ, Walsh JH, Soll AH: Regulation of neurotensin release from canine enteric primary cell cultures. J Physiol 250:G385-G390, 1986
Brunsson I, Eklund S, Fahrenkrug J, Jodal M, Lundgren O, Sjöqvist A: Effects of Substance P on intestinal secretion, blood flow, motility and release of vasoactive intestinal polypeptidein vivo in rat and cat. J Physiol 390:P255, 1987
Cassella RR, Brown AL, Jr, Sayre GP, Ellis FH Jr: Achalasia of the esophagus: Pathologic and etiologic considerations. Ann Surg 160:474–485, 1964
Holloway RH, Dodds WJ, Helm JF, Hogan WJ, Dent J, Arndorfer RC: Integrity of cholinergic innervation to the lower esophageal sphincter in achalasia. Gastroenterology 90:924–929, 1986
Howard ER, Garrett JR: Histochemistry and electron microscopy of rectum and colon in Hirschsprung's disease. Proc R Soc Med 63:20–22, 1970
Osaka M, Fujita T, Yanatori Y: On the possible role of intestinal hormones as the diarrhoeagenic messenger in cholera. Virchows Arch B Cell Pathol 18:287–296, 1975
Nilsson O, Cassuto J, Larsson P-A, Jodal M, Lidberg P, Ahlman H, Dahlström A, Lundgren O: 5-Hydroxytryptamine and cholera secretion: A histochemical and physiological study in cats. Gut 24:542–548, 1983
Beubler E, Kollar G, Saria A, Bukhave K, Rask-Madsen J: The role of 5-hydroxytryptamine and prostaglandin E2 in cholera toxin-induced fluid secretion in the small intestine of the ratin vivo. Gastroenterology 92:1315, 1987
Holmgren J: Actions of cholera toxin and the prevention and treatment of cholera. Nature 292:413–417, 1981
Cassuto J, Siewert A, Jodal M, Lundgren O: The involvement of intramural nerves in cholera toxin induced intestinal secretion. Acta Physiol Scand 117:195–202, 1983
Mathias JR, Sninsky CA: Motor effects of enterotoxins and laxatives.In Intestinal Absorption and Secretion. E Skadhauge, K Heintze (eds). Lancaster, Great Britian, MTP Press, 1984, pp 161–170
Stead RH, Tomioka M, Quinonez G, Simon GT, Felten SY, Bienenstock J: Intestinal mucosal mast cells in normal and nematode-infected rat intestines are in intimate contact with peptidergic nerves. Proc Natl Acad Sci USA 84:2975–2979, 1987
Castro GA, Harari Y, Russell D: Mediators of anaphylaxisinduced ion transport changes in small intestine. Am J Physiol 253:G540-G548, 1987
Sjöqvist A, Cassuto J, Jodal M, Brunsson I, Lundgren O: The effect on intestinal fluid transport of exposing the serosa to hydrochloric acid. A study of mechanisms. Acta Physiol Scand 116:447–454, 1982
Brunsson I, Sjöqvist A, Jodal M, Lundgren O: Mechanisms underlying intestinal fluid secretion evoked by nociceptive serosal stimulation of the rat. Naunyn-Schmiedeberg's Arch Pharmacol 328:439–445, 1985
Niakan E, Harati Y, Comstock JP: Diabetic autonomic neuropathy. Metabolism 35:224–234, 1986
Yagihashi S, Sima A: Diabetic autonomic neuropathy. The distribution of structural changes in sympathetic nerves in the BB rat. Am J Pathol 121:138–147, 1985
Belai A, Lincoln J, Milner P, Crowe R, Loesch A, Burnstock G: Enteric nerves in diabetic rats: Increase in vasoactive intestinal polypeptide but not substance P. Gastroenterology 89:967–976, 1985
Ballman M, Conlon JM: Changes in the somatostatin, substance P and vasoactive intestinal polypeptide content of the gastrointestinal tract following streptozotocininduced diabetes in the rat. Diabetologia 28:355–358, 1985
Scarpello JHB, Greaves M, Sladen GE: Small intestinal transit in diabetes. Br Med J 2:1225–1226, 1976
Scarpello JHB, Sladen GE: Diabetes and the gut. Gut 19:1153–1162, 1978
Chang EB, Bergenstal RM, Field M: Diabetic diarrhea: Loss of adrenergic regulation of intestinal fluid and electrolyte transport Gastroenterology. 84:1121, 1983
Chang CEB, Wang NS, Rao MC: Role of protein kinase C in intestinal anion secretion. Gastroenterology 88:1345, 1985
Chang EB, Fedorak RN, Field M: Experimental diabetic diarrhea in rats. Intestinal mucosal denervation hypersensitivity and treatment with clonidine. Gastroenterology 91:564–569, 1986
Fedorak RN, Field M, Chang EB: Treatment of diabetic diarrhea with clonidine. Ann Intern Med 102:197–199, 1985
Koberle F: Chagas' disease and Chagas' syndrome: The pathology of American trypanosamiasis. Adv Parasitol 6:63–116, 1968
Dos Santos R, de Gliveira R, Koberle F: Aspectos immunopatologices der destruriqao neuronal na moléstia de Chagas. Rev Goiana Med 22:235–243, 1976
Meneghelli VG: Chagas disease: A model of denervation in the study of digestive tract motility. Braz J Med Biol Res 18:255–264, 1985
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Research reported in this review and performed in the laboratories of the authors was sponsored by grants from the Swedish Medical Research Council (No. 2855 and 4984).
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Lundgren, O., Svanvik, J. & Jivegård, L. Enteric nervous system. Digest Dis Sci 34, 264–283 (1989). https://doi.org/10.1007/BF01536062
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DOI: https://doi.org/10.1007/BF01536062