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Colonic substance P levels are increased in ulcerative colitis and decreased in chronic severe constipation

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Abstract

Substance P content was determined by radioimmunoassay in colonic mucosa from 24 patients with chronic severe constipation, 16 with active ulcerative colitis, and 28 normal controls. In patients with chronic severe constipation, the mean concentration of substance P (19.9±8.2 pg/mg) was significantly lower than in normal subjects (71±18 pg/mg). In patients with ulcerative colitis, colonic substance P concentration in inflamed mucosa (170±46 pg/mg) was significantly higher than its levels in normal subjects. Substance P may therefore have a role in the pathogenesis of clinical conditions associated with diarrhea and constipation.

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Authors and Affiliations

  1. Department of Gastroenterology, Hadassah University Hospital, Hebrew University Hadassah Medical School, Israel

    Eran Goldin, Fanny Karmeli, ZVI Selinger & Daniel Rachmilewitz

  2. Department of Biological Chemistry, The Hebrew University, Jerusalem

    Eran Goldin, Fanny Karmeli, ZVI Selinger & Daniel Rachmilewitz

Authors
  1. Eran Goldin
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  2. Fanny Karmeli
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  3. ZVI Selinger
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  4. Daniel Rachmilewitz
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Goldin, E., Karmeli, F., Selinger, Z. et al. Colonic substance P levels are increased in ulcerative colitis and decreased in chronic severe constipation. Digest Dis Sci 34, 754–757 (1989). https://doi.org/10.1007/BF01540348

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  • DOI: https://doi.org/10.1007/BF01540348

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