Summary
Reperfusion of the ischemic intestine results in injury to the microvasculature and mucosal membrane. Inflammatory mediators released as a consequence of oxygen radical formation at the time of reperfusion promote neutrophil adhesion and emigration in postcapillary venules. Agents that interfere with leukocyte adherence afford significant protection against reperfusion injury.
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Abbreviations
- PMN:
-
polymorphonuclear leukocyte
- MPO:
-
myeloperoxidase
- I/R:
-
ischemia/reperfusion
- SOD:
-
superoxide dismutase
- LTB4 :
-
leukotriene B4
- PAF:
-
platelet activating factor
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Manuscripts published in this issue were the matter of a Symposium held at the University of Ulm, April 24–27, 1991
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Arndt, H., Kubes, P. & Granger, D.N. Involvement of neutrophils in ischemia-reperfusion injury in the small intestine. Klin Wochenschr 69, 1056–1060 (1991). https://doi.org/10.1007/BF01645158
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DOI: https://doi.org/10.1007/BF01645158