Abstract
Interdigestive motility of the small intestine was examined in 23 fasted healthy volunteers following luminal administration of the prostaglandins E2 and F2α. Motility was monitored by means of water-perfused catheters measuring intraluminal pressure changes. The registration points were located 25 cm apart, in the proximal duodenum, at the angle of Treitz, and in the jejunum. Prostaglandin E2 administered intraduodenally delayed the initiation of the subsequent activity front. The interval to the next activity front was prolonged by a dose of 1.0 mg prostaglandin E2 from 79.5±9.5 min to 137.1±5.0 min (P<0.01) and to 158.0±14.0 min by 2.0 mg prostaglandin E2 (P<0.05). Also, in four of seven experiments, a progressing activity front was arrested by 2.0 mg prostaglandin E2. Prostaglandin F2α at 2.5 or 5.0 mg given intraduodenally induced bursts of contractions with a frequency of 17.7± 0.8 contractions per minute and an amplitude of 10 to 110 mm Hg (P<0.07). In comparison, food intake produced irregular contractions at a frequency of 5.3± 1.8 contractions per minute and an amplitude of 10 to 50 mm Hg (P<0.05). It is concluded that prostaglandin E2 delays the initiation of activity fronts in the duodenum. In contrast, prostaglandin F2α changes the interdigestive motility pattern to one of intense contractile activity, which is different from the postprandial motility pattern.
Similar content being viewed by others
References
Hawkey CJ, Rampton DS: Prostaglandins and the gastrointestinal mucosa: Are they important in its function, disease, or treatment? Gastroenterology 89:1162–1188, 1985
Bennett A, Fleshler B: Prostaglandins and the gastrointestinal tract. Gastroenterology 59:790–800, 1970
Waller SL: Prostaglandins and the gastrointestinal tract. Gut 14:402–417, 1973
Karim SMM, Filshie GM: Therapeutic abortion using prostaglandin F2α. Lancet 1:157–159, 1970
Mukhopadhyay AK, Weisbrodt NW, Copeland ED, Johnson LR: Effect of prostaglandin E2 infusion on patterns of intestinal myoelectric activity. Gastroenterology 66:752, 1974
Konturek SJ, Thor P, Pawlik W, Gustaw P, Dembinski A: Role of prostaglandins in the myoelectric, motor, and metabolic activity of the small intestine in the dog.In Motility of the Digestive Tract. M Wienbeck (ed). New York, Raven Press, 1982, pp 437–444
Shehadeh Z, Price WE, Jacobson ED: Effects of vasoactive agents on intestinal blood flow and motility in the dog. Am J Physiol 216:386–392, 1969
Dajani EZ, Bertermann RE, Roge EAW, Schweingruber FL, Woods EM: Canine gastrointestinal motility effects of prostaglandin F2α in vivo. Arch Int Pharmacodyn 237:16–24, 1979
Befrits R, Johansson C: Oral PGE2 inhibits gastric acid secretion in man. Prostaglandins 29:143–152, 1985
Cummings JH, Newman A, Misiewicz JJ, Milton-Thompson GJ, Billings JA: Effect of intravenous prostaglandin F2α on small intestinal function in man. Nature 243:169–171, 1973
Vantrappen G, Janssens J, Hellemans J, Ghoos Y: The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine, J Clin Invest 59:1158–1166, 1977
Christensen J, Schedl HP; Clifton JA: The basic electrical rhythm of the duodenum in normal human subjects and in patients with thyroid disease. J Clin Invest 43:1659–1667, 1964
Sancholuz AG, Croley TE, Christensen J, Macagno EO, Glover JR: Phase lock of electrical slow waves and spike bursts in cat duodenum. Am J Physiol 229:608–612, 1975
Caprilli R, Melchiorri P, Improta G, Vernia P, Frieri G: Effects of bombesin and bombesin-like peptides on gastrointestinal myoelectric activity. Gastroenterology 68:1228–1235, 1975
Kerlin P, Zinsmeister A, Phillips S: Relationship of motility to flow of contents in the human small intestine. Gastroenterology 82:701–706, 1982
Bueno L, Fioramonti J, Ruckebusch Y: Rate of flow of digesta and electrical activity of the small intestine in dogs and sheep. J Physiol 249:69–85, 1975
Bukhave K, Rask-Madsen J: Saturation kinetics applied toin vitro effects of low prostaglandin E2 and F2α concentrations on ion transport across human jejunal mucosa. Gastroenterology 78:32–42, 1980
Johansson C, Ekelund K: Effects of 16, 16-dimethylprostaglandin E2 on the integrated response to a meal.In Gastrointestinal Motility in Health and Disease. HL Duthie (ed). Lancaster, MTP Press, 1978, pp 195–202
Bennett A, Murray JG, Wyllie JH: Occurrence of prostaglandin E2 in the human stomach and a study of its effects on human isolated gastric muscle. Br J Pharmac Chemother 32:339–349, 1968
Dooley CP, Mello WD, Valenzuela JE: Effects of aspirin and prostaglandin E2 on interdigestive motility complex and duodenogastric reflux in man. Dig Dis Sci 30:513–521, 1985
Fioramonti J, Bueno L: Gastrointestinal myoelectric activity disturbance in gastric ulcer disease in rats and dogs. Dig Dis Sci 25:575–580, 1980
Wingate DL: Backwards and forwards with the migrating complex. Dig Dis Sci 26:641–666, 1981
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tollström, T., Hellström, P.M., Johansson, C. et al. Effects of prostaglandins E2 and 552-01552-01552-01on motility of small intestine in man. Digest Dis Sci 33, 552–557 (1988). https://doi.org/10.1007/BF01798356
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01798356