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Inhibition of hepatic Na+, K+-adenosinetriphosphatase in taurolithocholate-induced cholestasis in the rat

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Summary

Na+, K+-adenosinetriphosphatase (Na+, K+-ATPase) activity was decreased in liver plasma membranes from rats in which cholestasis had been induced by i.v. administration of sodium taurolithocholate (5 μmoles/100 g b. wt). Incubation of liver plasma membranes with taurolithocholate (10–1300 μM) caused significant and dose dependent reductions of Na+, K+-ATPase activity at taurolithocholate concentrations above 100 μM. These findings lend support to the hypothesis that cholestasis induced by monohydroxy bile acids is at least partially the result of an inhibition of hepatic Na+, K+-ATPase activity.

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References

  1. B.G. Priestly, M.G. Côté and G.L. Plaa, Can. J. Physiol. Pharmac.49, 1078 (1971).

    Article  CAS  Google Scholar 

  2. J.E. King and L.J. Schoenfield, Proc. Mayo Clin.,47, 725 (1972).

    CAS  PubMed  Google Scholar 

  3. G.M. Murphy, F.H. Jansen and B.H. Billing, Biochem. J.129, 491 (1972).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. P. Back, Klin. Wschr.51, 926 (1973).

    Article  CAS  PubMed  Google Scholar 

  5. R.E. Jenner and E.R. Howard, Lancet2, 1073 (1977).

    Google Scholar 

  6. F. Schaffner and N.B. Javitt, Lab. Invest.15, 1783 (1966).

    CAS  PubMed  Google Scholar 

  7. N.B. Javitt and S. Emerman, J. clin. Invest.47, 1002 (1968).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. J.E. King and L.J. Schoenfield, J. clin. Invest.50, 2305 (1971).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. K. Miyai, V.M. Price and M.M. Fisher, Lab. Invest.24, 292 (1971).

    CAS  PubMed  Google Scholar 

  10. T. Layden and J.L. Boyer, Gastroenterology73, 120 (1977).

    Article  CAS  PubMed  Google Scholar 

  11. K. Miyai, A.L. Richardson, W. Mayr, and N.B. Javitt, Lab. Invest.36, 249 (1977).

    CAS  PubMed  Google Scholar 

  12. G. Kakis and I.M. Yousef, Gastroenterology75, 595 (1978).

    Article  CAS  PubMed  Google Scholar 

  13. S. Erlinger, D. Dhumeaux, P. Berthelot and M. Dumont, Am. J. Physiol.219, 416 (1970).

    Article  CAS  PubMed  Google Scholar 

  14. J.L. Boyer, Am. J. Physiol.221, 1156 (1971).

    Article  CAS  PubMed  Google Scholar 

  15. T.J. Layden and J.L. Boyer, J. clin. Invest.57, 1009 (1976).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. F.R. Simon, E. Sutherland and L. Accatino, J. clin. Invest.59, 849 (1977).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. C.S. Song, W. Rubin, A.B. Rifkind and A. Kappas, J. Cell Biol.41, 124 (1969).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. J. Reichen and G. Paumgartner, J. clin. Invest.60, 429 (1977).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. O. Lindberg and L. Ernster, Biochem. Analysis3, 1 (1956).

    CAS  Google Scholar 

  20. O. Bodansky and M.K. Schwartz, J. biol. Chem.238, 3420 (1963).

    Article  CAS  PubMed  Google Scholar 

  21. D.C. Earl and A. Korn, Biochem. J.94, 721 (1965).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. C. De Duve, B.C. Pressman, R. Gianetto, R. Wattiaux and F. Appelmans, Biochem. J.60, 604 (1955).

    Article  PubMed  PubMed Central  Google Scholar 

  23. E.F. Hartree, Analyt. Biochem.48, 422 (1972).

    Article  CAS  PubMed  Google Scholar 

  24. G. Paumgartner, W. Horak, P. Probst and G. Grabner, Naunyn Schmiedeberg's Arch. Pharmac.270, 98 (1971).

    Article  CAS  Google Scholar 

  25. K. Diem, Documenta Geigy scient. Tables, p. 145 (1962).

  26. B.L. Welch, Biometrika29, 350 (1937).

    Article  Google Scholar 

  27. G. Paumgartner, R. Herz, K. Sauter and H.P. Schwarz, Naunyn Schmiedeberg's Arch. Pharmac.285, 165 (1973).

    Article  Google Scholar 

  28. B.L. Blitzer and J.L. Boyer, J. clin. Invest.62, 1104 (1978).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. W.H. Evans, Biochem. J.116, 833 (1970).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. J.L. Dahl and L.E. Hokin, A. Rev. Biochem.43, 327 (1974).

    Article  CAS  Google Scholar 

  31. F. Bonvicini, A. Gautier and D. Gandiol, Lab. Invest.38, 487 (1978).

    Article  CAS  PubMed  Google Scholar 

  32. F.R. Simon, R. Sinensky, F. Kern and R.A. Davis, Clin. Res.25, 318 (1977).

    Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Pharmacology, University of Berne, CH-3010, Berne, Switzerland

    J. Reichen & G. Paumgartner

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  1. J. Reichen
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  2. G. Paumgartner
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Additional information

This work was supported by the Swiss National Science Foundation.

The authors thank Mr H. Sägesser and Miss B. Schütz for technical assistance.

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Reichen, J., Paumgartner, G. Inhibition of hepatic Na+, K+-adenosinetriphosphatase in taurolithocholate-induced cholestasis in the rat. Experientia 35, 1186–1188 (1979). https://doi.org/10.1007/BF01963278

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  • DOI: https://doi.org/10.1007/BF01963278

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