Skip to main content
SpringerLink
Log in

A pertussis toxin-sensitive G protein is required to induce histamine release from rat peritoneal mast cells by bradykinin

  • Histamine Release
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

Bradykinin, kallidin (Lys-bradykinin) and [Thi5,8,d-Phe7]-bradykinin a functional B2 antagonist, induce histamine release from rat peritoneal mast cells. The histamine release is dependent upon added calcium when mast cells are placed in calcium-free medium 30 min before being triggered with the kinins. Histamine release was dose-dependently inhibited by pertussis toxin (1–100 ng/ml) and by benzalkonium chloride (0.1–3 μg/ml). The efficiency of ionophore A23187 on histamine release was affected neither by pertussis toxin nor by benzalkonium chloride. The parallel responses of rat peritoneal mast cells to kinins and to substance P suggest that these peptides have the same mechanisms of action i.e. activation of a pertussis toxin-sensitive G protein and of phospholipase C defining a peptidergic triggering pathway of mast cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. M. Mousli, C. Bronner, J. L. Bueb, E. Tschirhart, J. P. Gies and Y. Landry,Activation of rat peritoneal mast cells by substance P and mastoparan. J. Pharmacol. exp. Ther.250, 329–335 (1989).

    PubMed  Google Scholar 

  2. P. Devillier, M. Renoux, G. Drapeau and D. Regoli,Histamine release from rat peritoneal mast cells by kinin antagonists. Eur. J. Pharmacol.149, 137–140 (1988).

    PubMed  Google Scholar 

  3. I. D. Lawrence, J. A. Warner, V. L. Cohan, L. M. Lichtenstein, A. Kagey-Sobotka, R. J. Vavrek, J. M. Stewart and D. Proud,Induction of histamine release from human skin mast cells by bradykinin analogs. Biochem. Pharmacol.38, 227–233 (1989).

    PubMed  Google Scholar 

  4. D. Regoli and J. Barabé,Pharmacology of bradykinin and related kinins. Pharmacol. Rev.32, 1–46 (1980).

    PubMed  Google Scholar 

  5. G. W. Read and E. F. Kiefer,Benzalkonium chloride: selective inhibitor of histamine release induced by compound 48/80 and other polyamines. J. Pharmacol. exp. Ther.211, 711–715 (1979).

    PubMed  Google Scholar 

  6. M. A. Lowman, R. C. Benyon and M. K. Church,Characterization of neuropeptide-induced histamine release from human dispersed skin mast cells. Br. J. Pharmacol.95, 121–130 (1988).

    PubMed  Google Scholar 

  7. F. L. Pearce, T. A. Kassessinoff and W. L. Liu,Characteristics of histamine secretion induced by neuropeptides: implications for the relevance of peptide-mast cell interactions in allergy and inflammation. Int. Arch. Allergy appl. Immunol.88, 129–131 (1989).

    PubMed  Google Scholar 

  8. C. Bronner, J. P. Gies, A. Vallé and Y. Landry,Preservation of the secretory response of peritoneal mast cells in the absence of extracellular calcium. Life Sci.41, 2555–2562 (1987).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire de Neuroimmunopharmacologie, Université Louis Pasteur-Strasbourg I, BP 24, 67401, Illkirch, France

    J. L. Bueb, M. Mousli, Y. Landry & C. Bronner

Authors
  1. J. L. Bueb
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Mousli
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Y. Landry
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. Bronner
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bueb, J.L., Mousli, M., Landry, Y. et al. A pertussis toxin-sensitive G protein is required to induce histamine release from rat peritoneal mast cells by bradykinin. Agents and Actions 30, 98–101 (1990). https://doi.org/10.1007/BF01969009

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01969009

Keywords

Search

Navigation