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Role of neutrophil-mediated inflammation in aspirin-induced gastric mucosal injury

  • Esophageal, Gastric, And Duodenal Disorders
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Abstract

The objectives of this study were to determine the roles of neutrophil-endothelial cell interactions and oxygen-derived free radicals in the pathogenesis of aspirin-induced gastric mucosal injury in rats. Oral administration of acidified aspirin (200 mg/kg) resulted in linear hemorrhagic erosions and an increase in myeloperoxidase activity, an index of neutrophil infiltration, in the gastric mucosa. Aspirin-induced gastric damage and the increase in myeloperoxidase activity were significantly inhibited by the injection of anti-CD11a, anti-CD11b, anti-intercellular adhesion molecule-1 monoclonal antibodies, and the combination of superoxide dismutase and catalase, which are scavengers of active oxygen species. These results suggest that neutrophil-endothelial adhesive interactions, which occur via CD11a/CD18-and CD11b/CD18-dependent interactions with intercellular adhesion molecule-1, and oxygen-derived free radicals produced by neutrophils are implicated in the production of aspirin-induced gastric mucosal injury.

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Yoshida, N., Yoshikawa, T., Nakamura, Y. et al. Role of neutrophil-mediated inflammation in aspirin-induced gastric mucosal injury. Digest Dis Sci 40, 2300–2304 (1995). https://doi.org/10.1007/BF02063228

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  • DOI: https://doi.org/10.1007/BF02063228

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