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Visceral perception in irritable bowel syndrome

Rectal and gastric responses to distension and serotonin type 3 antagonism

  • Intestinal Disorders, Inflammatory Bowel Disease, Immunology And Microbiology
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Abstract

We wished to determine if visceral perception in the rectum and stomach is altered in patients with irritable bowel syndrome and to evaluate the effects on visceral sensation of 5-HT3 receptor blockade. Twelve community patients with diarrhea-predominant irritable bowel syndrome and 10 healthy controls were studied in a double-blind, randomized, placebo-controlled study. Using two barostats, the stomach and rectum were distended, with pressure increments of 4 mm Hg, from 10 to 26 mm Hg; visceral perception was measured on an ordinal scale of 0–10. Personality traits were measured using standard psychological methods, and somatic pain was evaluated by immersion of the nondominant hand in cold water. The effect of 5-HT3 antagonism was tested with a single intravenous dose of ondansetron at 0.15 mg/kg. Gastric perception was higher in irritable bowel syndrome, but rectal distension was perceived similarly in irritable bowel syndrome and controls. Pain tolerance to cold water was also similar in irritable bowel syndrome and controls. Ondansetron induced rectal relaxation and increased rectal compliance but did not significantly alter gastric compliance or visceral perception. Psychological test scores were similar in patients and controls. We conclude that in this group of psychologically normal patients with irritable bowel syndrome, who were not chronic health-care seekers, visceral perception was normal. Ondansetron did not alter gut perception in health or in irritable bowel syndrome.

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Author notes

  1. Nicholas J. Talley MD, PhD

    Present address: University of Sydney, Clinical Sciences Building, Nepean Hospital, P.O. Box 63, NSW 2751, Penrith, Australia

Authors and Affiliations

  1. From the Division of Gastroenterology and Internal Medicine, Department of Health Sciences Research, Mayo Clinic and Foundation, 55905, Rochester, Minnesota

    Jaime Zighelboim MD,  Nicholas J. Talley MD, PhD, Sidney F. Phillips MD, William S. Harmsen MS & Alan R. Zinsmeister PhD

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  1. Jaime Zighelboim MD
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  2. Nicholas J. Talley MD, PhD
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  3. Sidney F. Phillips MD
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  4. William S. Harmsen MS
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  5. Alan R. Zinsmeister PhD
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Additional information

This work was supported in part by grants AG09440, DK32121, and RR585 from the National Institutes of Health.

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Zighelboim, J., Talley, N.J., Phillips, S.F. et al. Visceral perception in irritable bowel syndrome. Digest Dis Sci 40, 819–827 (1995). https://doi.org/10.1007/BF02064986

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  • DOI: https://doi.org/10.1007/BF02064986

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