Skip to main content
Log in

Gastric emptying of oil from solid and liquid meals

Effect of human pancreatic insufficiency

  • Motility, Nerve-Gut Interactions, Hormones, And Receptors
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

Digestion of fat in pancreatic insufficiency (PI) is strongly affected by how rapidly fat enters the duodenum. We postulated that: (1) oil empties faster in PI than in normals and (2) in both, it empties in a load-dependent fashion. We used a gamma camera to test these ideas by comparing gastric emptying of iodine-123 iodinated oil in normal and pancreatic-insufficient subjects after 15 g of free oil were ingested in a small spaghetti meal and 60 g of oil were ingested in a large spaghetti meal and in a milk emulsion. Indium-113m marked gastric emptying of water in the milk. In both groups after all meals, oil emptied fastest initially, slowing later; and oil emptied three to four times faster when 60 g vs 15 g were ingested. There were no significant differences between the groups of subjects with respect to gastric emptying of the spaghetti meals, but the pancreatic-insufficient subjects emptied both oil and water faster from the milk emulsion than did the normal subjects. The slower emptying of oil in the normal subjects was associated with significantly more layering of oil to the top of the intragastric milk emulsion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Edelbroek M, Horowitz M, Maddox A, Bellen J: Gastric emptying and intragastrastric distribution of oil in the presence of a liquid or a solid meal. J Nucl Med 33:1283–1290, 1992

    PubMed  Google Scholar 

  2. Meyer JH, Elashoff JD, Domeck M, Levy A, Jehn D, Hlinka M, Lake R, Graham LS, Gu YG: Control of canine gastric emptying of fat by lipolytic products. Am J Physiol 266:G1017-G1035, 1994

    PubMed  Google Scholar 

  3. Meyer JH, Gu YG, Doty JE: Effect of replenished lipase on postcibal absorption of fat in a canine model of pancreatic insufficiency. Pancreas 9:494–500, 1994

    PubMed  Google Scholar 

  4. Meyer JH, Gu YG, Jehn D, Doty JE: Factors which affect the performance of lipase on fat digestion in a canine model of pancreatic insufficiency. Pancreas 9:613–623, 1994

    PubMed  Google Scholar 

  5. Meyer JH: Delivery of pancreatic enzymes in microsphere preparations: transit, timing, physiological needs.In Pancreatic Enzymes in Health and Disease. PG Lankisch (ed). Springer-Verlag, Berlin, 1991, pp 71–88

    Google Scholar 

  6. Wollaeger EE, Comfort MW, Clagget OT, Osterberg AE: Efficiency of the gastrointestinal tract after resection of head of pancreas. JAMA 137:838–848, 1948

    Google Scholar 

  7. Durie PR, Bell L, Linton W, et al: Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis. Gut 21:778–786, 1980

    PubMed  Google Scholar 

  8. Meyer JH, VanDeventer G, Graham LS, Thomson J, Thomasson D: Error and corrections in scintigraphic measurement of gastric emptying of solid foods. J Nucl Med 24:197–203, 1983

    PubMed  Google Scholar 

  9. Meyer JH, Hlinka M, Khatibi A, Raybould HE, Tso P: Role of small intestine in caloric compensations to oil premeals in rats. Am J Physiol (submitted)

  10. Lin HC, Elashoff JD, Gu YG, Meyer JH: Effect of meal volume on gastric emptying. J Gastrointest Motil 4:157–163, 1992

    Google Scholar 

  11. Carney BI, Jones KL, Horowitz M, Sun WM, Penagini R, Meyer JH: Gastric emptying of oil and aqueous meal components in human pancreatic insufficiency: Effects of posture and on appetite. Am J Physiol 268:G925-G932, 1995

    PubMed  Google Scholar 

  12. Brener W, Hendrix TR, McHugh PR: Regulation of the gastric emptying of glucose. Gastroenterology 85:76–82, 1983

    PubMed  Google Scholar 

  13. Hunt JN, Smith JL, Jiang CL: Effects of meal volume and energy density on the gastric emptying of carbohydrates. Gastroenterology 89:1326–1330, 1985

    PubMed  Google Scholar 

  14. Horowitz M, Maddox A, Bochner M, Wishart J, Bratasiuk R, Collins P, Shearman D: Relationships between gastric emptying of solid and caloric liquid meals and alcohol absorption. Am J Physiol 257:G291-G298, 1989

    PubMed  Google Scholar 

  15. Regan PT, Malagelada JR, DiMagno EP, Go VLW: Postprandial gastric function in pancreatic insufficiency. Gut 20:249–254, 1979

    PubMed  Google Scholar 

  16. Long WB, Weiss JB: Rapid gastric emptying of fatty meals in pancreatic insufficiency. Gastroenterology 67:920–925, 1974

    PubMed  Google Scholar 

  17. Lin HC, Doty JE, Reedy TJ, Meyer JH: Inhibition of gastric emptying by sodium oleate depends on the length of gut exposed to the nutrient. Am J Physiol 259:G1031-G1036, 1990

    PubMed  Google Scholar 

  18. Hunt JN, Knox MT: A relation between the chain length of fatty acids and the slowing of gastric emptying. J Physiol (London) 194:327–336, 1968

    PubMed  Google Scholar 

  19. Meyer JH, Mayer EA, Jehn D, Gu YG, Fried M, Fink AS: Gastric processing and emptying of fat. Gastroenterology 90:1176–1187, 1986

    PubMed  Google Scholar 

  20. Hunt JN, Stubbs DF: The volume and energy content of meals as determinants of gastric emptying. J Physiol (London) 215:209–225, 1975

    Google Scholar 

  21. Weiner K, Grahn LS, Reedy T, Elashoff J, Meyer JH: Simultaneous gastric emptying of two solid foods. Gastroenterology 81:257–266, 1981

    PubMed  Google Scholar 

  22. Lin HC, Kim BH, Elashoff JD, Doty JE, Gu YG, Meyer JH: Gastric emptying of solid food is most potently inhibited by carbohydrate in canine distal ileum. Gastroenterology 102:793–801, 1992

    PubMed  Google Scholar 

  23. Debas HT: Peripheral regulation of gastric acid secretion.In Physiology of the Gastrointestinal Tract. Vol 2, 2nd ed. JR Johnson, J Christensen, MJ Jackson, ED Jacobson, JH Walsh (eds). New York, Raven Press, 1987, pp 931–945

    Google Scholar 

  24. Meyer JH, Stevenson EA, Watts HD: The potential role of protein in the absorption of fat. Gastroenterology 70:232–239, 1976

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Meyer, J.H., Hlinka, M., Kao, D. et al. Gastric emptying of oil from solid and liquid meals. Digest Dis Sci 41, 1691–1699 (1996). https://doi.org/10.1007/BF02088732

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02088732

Key words

Navigation