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Pancreatic lesions and modifications of pancreatic juice in tropical chronic pancreatitis (tropical calcific diabetes)

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Abstract

Seventeen Indian patients from Kerala State and 13 Indian controls were submitted to a dietary inquiry. Indian patients and controls had a low fat intake (40.8 g±12.1 and 34.5 g±11.0 per day, respectively) and a moderately low protein intake (52.8±9.5 and 47.8±11.3 g per day); 11 patients and 6 controls did not consume cassava. Pure nonactivated pancreatic juice was collected at endoscopy in 10 Indian patients who presented with tropical calcific diabetes, 12 apparently normal controls from the same area, and 23 apparently normal French controls. The only significant differences between Indian and French controls was a decreased pancreatic protein response to cerulein and an increased calcium concentration in the Indian subjects. The pancreatic juice of Indian patients was characterized by decreased volume, normal bicarbonate concentration, increased protein concentration when the acinar cells were not stimulated, with no response to cerulein, increased calcium concentration, and normal citrate concentration. These changes are very similar to the changes observed in French patients with chronic alcoholic pancreatitis. The lesions of 14 surgical resection pancreatic specimens from South Indian patients presenting with tropical pancreatitis were compared to pancreata from French patients presenting with chronic alcoholic pancreatitis. The only difference was that intraductal plugs, lesions of the duct epithelium, and retention cysts or pseudocysts were less frequent in Indians. These results show that the two nutritional forms of pancreatic lithiasis, alcoholic and tropical, have similar histological lesions and biochemical modifications of pancreatic juice. Increased calcium concentration must play an important role in the formation of calcium salt calculi. Increased protein concentration in pancreatic juice, which is found both in alcoholism and hypercalcemia, also contributes to lithogenesis by facilitating heteregeneous crystallization.

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Authors and Affiliations

  1. From the Clinique des Maladies de l'Appareil Digestif et de la Nutrition Hôpital Sainte-Marguerite, B.P. 29, 13277, Marseille Cedex 9, France

    H. Sarles PhD, P. Augustine MD, R. Laugier MD, S. Mathew MD & P. Dupuy BS

  2. INSERM U 315, 46, boulevard de la Gaye, 13009, Marseille, France

    H. Sarles PhD, P. Augustine MD, R. Laugier MD, S. Mathew MD & P. Dupuy BS

  3. Deva Matha Hospital, Koothattuukulam, Ernakulam, 688 662, Kerala, India

    H. Sarles PhD, P. Augustine MD, R. Laugier MD, S. Mathew MD & P. Dupuy BS

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  1. H. Sarles PhD
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  2. P. Augustine MD
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  3. R. Laugier MD
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  4. S. Mathew MD
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  5. P. Dupuy BS
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This work was supported by a grant from the Institut National de la Santé et de la Recherche Médicale No. 487 NS 5 Nord Sud.

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Sarles, H., Augustine, P., Laugier, R. et al. Pancreatic lesions and modifications of pancreatic juice in tropical chronic pancreatitis (tropical calcific diabetes). Digest Dis Sci 39, 1337–1344 (1994). https://doi.org/10.1007/BF02093802

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  • DOI: https://doi.org/10.1007/BF02093802

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