Abstract
Erythromycin and related macrolides act as smooth muscle and neural receptors to contract rabbit duodenum and induce phase III migrating motor complex (MMC) activity in intact dogs. A recently developed motilin antagonist confirms that motility effects of erythromycin are mediated by motilin receptors. Despite species, organ, and tissue heterogeneity of motilin receptors, binding experiments with rodent antral smooth muscle tissue provide a good model for the development of this new class of prokinetics.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Itoh Z, Nakaya M, Suzuki T, Arai H, Wakabayashi K: Erythromycin mimics exogenous motilin in gastrointestinal contractile activity in the dog. Am J Physiol 247:G688-G694, 1984
Zara GP, Thompson HH, Pilot MA, Ritchie HD: Effects of erythromycin on gastrointestinal tract motility. J Antimicrob Chemother 16:175–179, 1985
Otterson MF, Sarna SK: Gastrointestinal motor effects of erythromycin. Am J Physiol 259:G355-G363, 1990
Peeters TL: Erythromycin and other macrolides as prokinetic agents. Relation with motilin. Gastroenterology 105:1886–1899, 1993
Peeters TL, Depoortere I, Macielag MJ, Dharanipragada R, Florance J, Marvin MS, Vantrappen G, Galdes A:In vitro evaluation of the potent motilin antagonist ANQ-11168. Gastrointest Motil 5:210, 1993
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Peeters, T.L., Depoortere, I. Motilin receptor: A model for development of prokinetics. Digest Dis Sci 39 (Suppl 12), 76S–78S (1994). https://doi.org/10.1007/BF02300377
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02300377