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Young adulthood body mass index and risk of cancer in later adulthood: historical cohort study

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Abstract

Objective

To investigate the relationship between body mass index (BMI) in young adulthood and cancer incidence and mortality.

Methods

A total of 9,549 men and 2,657 women had weight and height measured while at university (1948–1968). Participants were traced through the National Health Service Central Register, and cancer registration and death certificates were obtained. Cox proportional hazard models were used to estimate hazard ratios (HR) of associations between BMI and cancer incidence and mortality.

Results

The mean age at university was 20 years. During a median follow-up of 49 years, 2,349 deaths occurred, including 55 breast, 111 prostate, and 131 colorectal cancer. There were 1,305 cancer registrations, including 102 breast, 211 prostate, and 125 colorectal cancers. There was weak evidence of an association between BMI and colorectal cancer incidence (adjusted HR per 1 kg/m2: 1.06, 95% CI: 0.98–1.15) and mortality (HR 1.05, 95% CI: 0.98–1.14). There was no evidence of an association between BMI and either breast or prostate cancer.

Conclusions

Targeting a reduction in obesity in young adulthood may prevent a significant number of colorectal cancer deaths, although whether this relationship is direct or through tracking to later adult BMI has yet to be established.

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Acknowledgment

Anya Burton is a recipient of a PhD studentship from the Medical Research Council.

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Authors and Affiliations

  1. Department of Social Medicine, University of Bristol, 39 Whatley Road, Canynge Hall, Bristol, BS8 2PS, UK

    Anya Burton, Richard Martin, Bruna Galobardes & Mona Jeffreys

  2. Department of Social Medicine, MRC CAiTE Centre, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK

    Anya Burton, Richard Martin & George Davey Smith

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  1. Anya Burton
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  2. Richard Martin
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  3. Bruna Galobardes
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Correspondence to Mona Jeffreys.

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Burton, A., Martin, R., Galobardes, B. et al. Young adulthood body mass index and risk of cancer in later adulthood: historical cohort study. Cancer Causes Control 21, 2069–2077 (2010). https://doi.org/10.1007/s10552-010-9625-3

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  • DOI: https://doi.org/10.1007/s10552-010-9625-3

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