Skip to main content

Advertisement

SpringerLink
Log in

Adiposity and the risk of colorectal adenomatous polyps: a meta-analysis

  • Original paper
  • Published:
Cancer Causes & Control Aims and scope Submit manuscript

Abstract

Objective

The findings from epidemiological studies addressing the association between adiposity and the risk of colorectal adenomatous polyps are inconsistent. We performed a meta-analysis of epidemiological studies including cross-sectional, case–control, and cohort studies.

Methods

We searched PubMed and EMBASE in June, 2010. All searched articles were reviewed and selected independently by two evaluators according to pre-determined selection criteria.

Results

We included 25 studies (nine cross-sectional studies, eleven case–control studies, and five prospective cohort studies) that comprised a total of 300,671 participants and 20,903 cases in the final analysis. When all studies were pooled, the odds ratio (OR) or relative risk (RR) of adiposity and abdominal adiposity for colorectal adenomatous polyp risk was 1.43 (95% confidence interval (CI) 1.23–1.67; n = 22) and 1.42 (95% CI 1.30–1.56; n = 12), respectively. Similarly, an increased risk of colorectal adenomatous polyps was observed in most of the subgroup meta-analyses.

Conclusions

Overall, we found that adiposity and abdominal adiposity significantly increased the risk of colorectal adenomatous polyps in a meta-analysis of epidemiological studies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Markowitz SD, Bertagnolli MM (2009) Molecular basis of colorectal cancer. N Engl J Med 361:2449–2460

    Article  PubMed  CAS  Google Scholar 

  2. Levine JS, Ahnen DJ (2006) Adenomatous polyps of the colon. N Engl J Med 355:2551–2557

    Article  PubMed  CAS  Google Scholar 

  3. Grahn SW, Varma MG (2008) Factors that increase risk of colon polyps. Clin Colon Rectal Surg 21:247–255

    Article  PubMed  Google Scholar 

  4. American Cancer Society (2007) Global cancer facts and figures 2007. American Cancer Society, Atlanta, Georgia, p 12

    Google Scholar 

  5. Jemal A, Siegel R, Ward E et al (2008) Cancer statistics, 2008. CA Cancer J Clin 58:71–96

    Article  PubMed  Google Scholar 

  6. Bayerdorffer E, Mannes GA, Ochsenkuhn T et al (1993) Increased risk of ‘high-risk’ colorectal adenomas in overweight men. Gastroenty 104:137–144

    CAS  Google Scholar 

  7. Shinchi K, Kono S, Honjo S et al (1994) Obesity and adenomatous polyps of the sigmoid colon. Jpn J Cancer Res 85:479–484

    PubMed  CAS  Google Scholar 

  8. Kim CS, Kim MC, Cheong HK et al (2005) The association of obesity and left colonic adenomatous polyps in Korean adult men. J Prev Med Public Health 38(4):415–419

    PubMed  Google Scholar 

  9. Morita T, Tabata S, Mineshita M et al (2005) The metabolic syndrome is associated with increased risk of colorectal adenoma development: the self-defense forces health study. Asian Pacific J Cancer Prev 6:485–489

    Google Scholar 

  10. Wang Y, Lin S, Lai W et al (2005) Association between adenomas of rectosigmoid colon and metabolic syndrome features in a Chinese population. J Gastr Hep 20:1410–1415

    Article  Google Scholar 

  11. Anderson JC, Messina CR, Dakhllalah F et al (2007) Body mass index: a marker for significant colorectal neoplasia in a screening population. J Clin Gastroenterol 41:285–290

    Article  PubMed  Google Scholar 

  12. Kim JH, Lim YJ, Kim YH et al (2007) Is metabolic syndrome a risk factor for colorectal adenoma? Cancer Epidemiol Biomarkers Prev 16(8):1543–1546

    Article  PubMed  CAS  Google Scholar 

  13. Lee GE, Park HS, Yun KE et al (2008) Association between BMI and metabolic syndrome and adenomatous colonic polyps in Korean men. Obesity 16:1434–1439

    Article  PubMed  Google Scholar 

  14. Leitzmann MF, Flood A, Ferrucci LM et al (2009) Adiposity in relation to colorectal adenomas and hyperplastic polyps in women. Cancer Causes Control 20:1497–1507

    Article  PubMed  Google Scholar 

  15. Neugut AI, Lee WC, Garbowski GC et al (1991) Obesity and colorectal adenomatous polyps. J Natl Cancer Inst 83:359–361

    Article  PubMed  CAS  Google Scholar 

  16. Olsen J, Kronborg O, Lynggaard J, Ewertz M (1994) Dietary risk factors for cancer and adenomas of the large intestine. A case-control study within a screening trial in Denmark. Eur J Cancer 30A(1):53–60

    Article  PubMed  CAS  Google Scholar 

  17. Bird CL, Frankl HD, Lee ER et al (1998) Obesity, weight gain, large weight changes, and adenomatous polyps of the left colon and rectum. Am J Epidemiol 147:670–680

    PubMed  CAS  Google Scholar 

  18. Takemura Y, Kikuchi S, Oba K et al (2000) A high level of physical fitness during thirties is a negative risk factor for colonic polyps during fifties. Keio J Med 49(3):111–116

    PubMed  CAS  Google Scholar 

  19. Almendingen K, Hofstad B, Vant MH (2001) Does high body fatness increase the risk of presence and growth of colorectal adenomas followed up in situ for 3 years? Am J Gastroenterol 96:2238–2246

    Article  PubMed  CAS  Google Scholar 

  20. Boutron MC, Senesse P, Meance S et al (2001) Energy intake, body mass index, physical activity and the colorectal adenoma-carcinoma sequence. Nutr Cancer 39(1):50–57

    Article  Google Scholar 

  21. Morimoto LM, Newcomb PA, Ulrich CM et al (2002) Risk factors for hyperplastic and adenomatous polyps: evidence for malignant potential? Cancer Epidemiol Biomarkers Prev 11:1012–1018

    PubMed  Google Scholar 

  22. Hauret KG, Bostick RM, Matthews CE et al (2004) Physical activity and reduced risk of incident sporadic colorectal adenomas; observational support for mechanisms involving energy balance and inflammation modulation. Am J Epidemiol 159:983–992

    Article  PubMed  Google Scholar 

  23. Chung YW, Han DS, Park YK et al (2006) Association of obesity, serum glucose and lipids with the risk of advanced colorectal adenoma and cancer: a case-control study in Korea. Dig Liver Dis 38:668–672

    Article  PubMed  CAS  Google Scholar 

  24. Wolf LA, Terry PD, Potter JD et al (2007) Do factors related to endogenous and exogenous estrogens modify the relationship between obesity and risk of colorectal adenomas in women? Cancer Epidemiol Biomarkers Prev 16(4):676–683

    Article  PubMed  CAS  Google Scholar 

  25. Omata F, Brown WR, Tokuda Y et al (2009) Modifiable risk factors for colorectal neoplasms and hyperplastic polyps. Inter Med 48:123–128

    Article  Google Scholar 

  26. Giovannucci E, Ascherio A, Rimm EB et al (1995) Physical activity, obesity, and risk for colon cancer and adenoma in men. Ann Intern Med 122:327–334

    PubMed  CAS  Google Scholar 

  27. Giovannucci E, Colditz GA, Stampfer MJ, Willett WC (1996) Physical activity, obesity, and risk of colorectal adenoma in women (United States). Cancer Causes Control 7:253–263

    Article  PubMed  CAS  Google Scholar 

  28. Kahn HS, Tatham LM, Thun MJ, Heath CW (1998) Risk factors for self-reported colon polyps. J Gen Intern Med 13:303–310

    Article  PubMed  CAS  Google Scholar 

  29. Sedjo RL, Byers T, Levin TR et al (2007) Change in body size and the risk of colorectal adenomas. Cancer Epidemiol Biomarkers Prev 16(3):526–531

    Article  PubMed  Google Scholar 

  30. Wise LA, Rosenberg L, Palmer JR et al (2008) Anthropometric risk factors for colorectal polyps in African-American woman. Obesity 16:859–868

    Article  PubMed  Google Scholar 

  31. Wells GA, Shea B, O’Connell D et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses. http://www.ohri.ca/programs/clinical_epidemiology/oxford.htm

  32. WHO Expert Consultation (2004) Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 363:157–163

    Article  Google Scholar 

  33. Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539–1558

    Article  PubMed  Google Scholar 

  34. Woolf B (1955) On estimating the relation between blood group and disease. Ann Hum Genet 19:251–253

    Article  PubMed  CAS  Google Scholar 

  35. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188

    Article  PubMed  CAS  Google Scholar 

  36. Martinez ME, Baron JA, Lieberman DA et al (2009) A pooled analysis of advanced colorectal neoplasia diagnoses after colonoscopic polypectomy. Gastroenterol 136:832–841

    Article  Google Scholar 

  37. Schoen RE, Tangen CM, Kuller LH et al (1999) Increased blood glucose and insulin, body size, and incident colorectal cancer. J Natl Cancer Inst 91:1147–1154

    Article  PubMed  CAS  Google Scholar 

  38. Schoen RE, Weissfeld JL, Kuller LH et al (2005) Insulin-like growth factor-1 and insulin are associated with the presence and advancement of adenomatous polyps. Gastroenterol 129:464–475

    Google Scholar 

  39. Erarslan E, Turkay C, Koktener A, Koca C, Uz B, Bavbek N (2009) Association of visceral fat accumulation and adiponectin levels with colorectal neoplasia. Diag Dis Sci 54:862–868

    Article  CAS  Google Scholar 

  40. Gonullu G, Kahraman H, Bedir A, Bektas A, Yucel I (2010) Association between adiponectin, resistin, insulin resistance, and colorectal tumors. Int J Colorectal Dis 25:205–212

    Article  PubMed  Google Scholar 

  41. Gallagher EJ, Fierz Y, Ferguson RD, LeRoith D (2010) The pathway from diabetes and obesity to cancer on the route to targeted therapy. Endocr Pract 16(5):864–873

    Article  PubMed  Google Scholar 

  42. Fufisawa T, Endo H, Tomimoto A et al (2008) Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition. Gut 57:1531–1538

    Article  Google Scholar 

  43. Moghaddam AA, Woodward M, Huxley R (2007) Obesity and risk of colorectal cancer: a meta-analysis of 31 studies with 70,000 events. Cancer Epidemiol Biomarkers Rrev 16(12):2533–2547

    Article  Google Scholar 

  44. Larsson SC, Wolk A (2007) Obesity and colon and rectal cancer risk: a meta-analysis of prospective studies. Am J Clin Nutr 86:556–565

    PubMed  CAS  Google Scholar 

  45. Dai Z, Xu Y, Niu L (2007) Obesity and colorectal cancer risk: a meta-analysis of cohort studies. World J Gastroenterol 13(31):4199–4206

    PubMed  Google Scholar 

Download references

Acknowledgment

This work was supported by INHA University Research Grant.

Author information

Authors and Affiliations

  1. Department of Family Medicine, School of Medicine, Inha University, Incheon, Republic of Korea

    Yeon Ji Lee & Ji-Ho Choi

  2. Cancer Epidemiology Branch, Research Institute, Smoking Cessation Clinic, Family Medicine Clinic, and Center for Cancer Prevention and Detection, Hospital, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang, Gyeonggi-do, 410-769, Republic of Korea

    Seung-Kwon Myung

  3. Health Promotion Center, Department of Family Medicine, Seoul National University Hospital, Seoul, Republic of Korea

    BeLong Cho, Jin Ho Park & Min-Sun Park

  4. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea

    Byung-Joo Park

  5. Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Seoul, Republic of Korea

    Woong Ju

Authors
  1. Yeon Ji Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Seung-Kwon Myung
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. BeLong Cho
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Byung-Joo Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jin Ho Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Woong Ju
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Min-Sun Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Ji-Ho Choi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Seung-Kwon Myung.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lee, Y.J., Myung, SK., Cho, B. et al. Adiposity and the risk of colorectal adenomatous polyps: a meta-analysis. Cancer Causes Control 22, 1021–1035 (2011). https://doi.org/10.1007/s10552-011-9777-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10552-011-9777-9

Keywords

Search

Navigation