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High Prevalence of Gastric Preneoplastic Lesions in East Asians and Hispanics in the USA

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Abstract

Background

The prevalence of H. pylori infection and the incidence of gastric cancer differ widely around the world, but it is unclear whether these differences are mirrored in the multiethnic population of the USA.

Aims

This study tested the hypothesis that the prevalence of both H. pylori infection and gastric preneoplastic lesions in US residents of Hispanic and Asian ancestry reflects the incidence of gastric cancer in their ancestral countries.

Methods

A total of 799,075 subjects with gastric biopsies extracted from a national pathology database were stratified into the following ancestries: Indian, Hispanic, Vietnamese, Chinese, Japanese Korean, and other Americans (Caucasian and African-American US residents). The prevalence of H. pylori, intestinal metaplasia, and atrophic gastritis was compared among different ethnic groups using age- and sex-adjusted odds ratios and linear regression.

Results

Patients of Indian, Hispanic, Vietnamese, Chinese, Japanese, and Korean ancestry had significantly higher prevalence rates of H. pylori gastritis, intestinal metaplasia, and atrophy than other Americans. The prevalence of intestinal metaplasia and atrophy among different ethnic groups did not correlate with H. pylori prevalence, but did correlate highly significantly with gastric cancer incidence in the patients’ ancestral countries.

Conclusions

Various US ethnic groups have significantly different prevalence rates of H. pylori gastritis and gastric preneoplastic lesions. Patients’ ethnicity needs be considered in the prevention and early detection of gastric cancer.

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Conflict of interest

Kevin Turner and Robert Genta are employees of Miraca Life Sciences. Christie Choi and Amnon Sonnenberg declare no relevant conflicts.

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Authors and Affiliations

  1. Miraca Life Sciences Research Institute, Irving, TX, USA

    Christie E. Choi, Kevin Turner & Robert M. Genta

  2. Department of Medicine, University of Texas Southwestern Medical School, Dallas, TX, USA

    Christie E. Choi

  3. Department of Pathology, University of Texas Southwestern Medical School, Dallas, TX, USA

    Kevin Turner

  4. Departments of Pathology and Medicine, University of Texas Southwestern Medical School, Dallas, TX, USA

    Robert M. Genta

  5. Department of Medicine (Gastroenterology), Portland VAMC, OHSU, Portland, OR, USA

    Amnon Sonnenberg

Authors
  1. Christie E. Choi
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  2. Amnon Sonnenberg
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  3. Kevin Turner
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  4. Robert M. Genta
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Corresponding author

Correspondence to Robert M. Genta.

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Choi, C.E., Sonnenberg, A., Turner, K. et al. High Prevalence of Gastric Preneoplastic Lesions in East Asians and Hispanics in the USA. Dig Dis Sci 60, 2070–2076 (2015). https://doi.org/10.1007/s10620-015-3591-2

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  • DOI: https://doi.org/10.1007/s10620-015-3591-2

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