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Familial gastric cancer: guidelines for diagnosis, treatment and periodic surveillance

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Abstract

Hereditary diffuse gastric cancer (HDGC) is a relatively rare disorder, with a mutated CDH1 gene as the only known cause. Carriers of a germline mutation in CDH1 have a lifetime risk of >80% of developing diffuse gastric cancer. As periodic gastric surveillance is of limited value in detecting early stages of HDGC, prophylactic gastrectomy is advised for this patient group. Little is known about other types of familial gastric cancer. The Dutch working group on hereditary gastric cancer has formulated guidelines for various aspects of medical management for families and individuals at high risk of developing gastric cancer, including criteria for referral, classification, diagnostics, and periodic gastric surveillance. These guidelines are not limited to HDGC and are therefore partially complementary to the guidelines on hereditary diffuse gastric cancer of the international gastric cancer linkage consortium (IGCLC 2010). In order to optimize the care and increase the knowledge on hereditary gastric cancer it is important to centralize medical care for these patients. National and international collaboration is warranted to improve the quality of research by increasing the size of study cohorts.

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Author information

Authors and Affiliations

  1. Family Cancer Clinic, The Netherlands Cancer Institute, Amsterdam, The Netherlands

    Irma Kluijt

  2. Departments of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands

    Rolf H. Sijmons

  3. Departments of Human Genetics, Medical Centre, Radboud University Nijmegen, Nijmegen, The Netherlands

    Nicoline Hoogerbrugge & Marjolijn Ligtenberg

  4. Surgical Oncology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands

    John T. Plukker

  5. Departments of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

    Daphne de Jong

  6. Pathology, Medical Centre, Radboud University Nijmegen, Nijmegen, The Netherlands

    J. Han van Krieken & Marjolijn Ligtenberg

  7. Department of Surgical Oncology, University Medical Centre Utrecht, Utrecht, The Netherlands

    Richard van Hillegersberg

  8. Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

    Eveline Bleiker

  9. Gastroenterology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

    Anemieke Cats

Authors
  1. Irma Kluijt
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  2. Rolf H. Sijmons
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  3. Nicoline Hoogerbrugge
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  4. John T. Plukker
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  5. Daphne de Jong
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  6. J. Han van Krieken
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  7. Richard van Hillegersberg
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  8. Marjolijn Ligtenberg
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  9. Eveline Bleiker
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  10. Anemieke Cats
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Corresponding author

Correspondence to Irma Kluijt.

Additional information

This study is conducted on behalf of the Dutch Working Group on Hereditary Gastric Cancer

Please refer the Appendix section for Dutch Working Group on Hereditary Gastric Cancer group members

Appendix

Appendix

Clinical Genetics: M. G. E. M. Ausems (Utrecht), N. Hoogerbrugge (Nijmegen), I. Kluijt (Amsterdam), R. H. Sijmons (Groningen), A. Wagner (Rotterdam)

Gastroenterologists: A. Cats, E. Dekker, K. Tytgat (Amsterdam), J. H. Kleibeuker (Groningen), H. F. A. Vasen (The Netherlands Foundation for Detection of Hereditary Tumours)

Molecular Genetics: M. Ligtenberg (Nijmegen)

Surgical Oncology: R. van Hillegersberg (Utrecht), J. T. Plukker (Groningen)

Pathology: N. C. T. van Grieken (Amsterdam), D. de Jong (Amsterdam), J. H. van Krieken (Nijmegen)

Psychology: E. Bleiker (Amsterdam)

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Kluijt, I., Sijmons, R.H., Hoogerbrugge, N. et al. Familial gastric cancer: guidelines for diagnosis, treatment and periodic surveillance. Familial Cancer 11, 363–369 (2012). https://doi.org/10.1007/s10689-012-9521-y

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  • DOI: https://doi.org/10.1007/s10689-012-9521-y

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