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Successful allogeneic hematopoietic stem cell transplantation for chronic granulomatous disease with inflammatory complications and severe infection

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Abstract

We report two patients with chronic granulomatous disease (CGD). The first patient presented with granulomatous colitis and pulmonary aspergillosis, and the second patient with liver abscess and restrictive pulmonary disorder. Both patients underwent allogeneic hematopoietic stem cell transplantation, the first from an HLA-matched sibling donor, and the second from an HLA-matched unrelated donor, after preconditioning with fludarabine, anti-thymocyte globulin, cyclophosphamide, and total-body irradiation of 3 Gy. The engraftment was prompt and the regimen-related toxicity was mild. The patients are able to return to their daily lives with full donor chimerism, although the second patient underwent a living-related-donor orthotopic liver transplantation from his mother for chronic liver graft-versus-host disease. The conditioning regimen we used was feasible and applicable to patients with CGD accompanied by inflammatory disease and severe infection.

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Acknowledgments

We must clarify M.T. is a recipient of Grant for Research on Allergic disease and Immunology (H20-016) from Japanese Ministry of Health, Labor and Welfare.

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Author notes

  1. Yasuko Kojima & Kazumasa Mitsui

    Present address: Department of Pediatrics, Toho University Omori Medical Center, Tokyo, Japan

  2. Kazuko Kudo

    Present address: Division of Hematology and Oncology, Shizuoka Children’s Hospital, Sizuoka, Japan

Authors and Affiliations

  1. Division of Pediatric Hematology and Oncology, Ibaraki Children’s Hospital, Futaba-dai, 3-3-1, Mito, Ibaraki, 311-4145, Japan

    Keisuke Kato, Yasuko Kojima, Chie Kobayashi, Kazumasa Mitsui, Ryoko Nakajima-Yamaguchi, Kazuko Kudo, Ai Yoshimi, Tomohei Nakao, Kazutoshi Koike & Masahiro Tsuchida

  2. Division of Pediatric Surgery, Ibaraki Children’s Hospital, Mito, Ibaraki, Japan

    Toshihiro Yanai

  3. Department of Pediatrics and Developmental Biology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

    Tomohiro Morio

  4. Department of Transplant Surgery, National Center for Child Health and Development, Tokyo, Japan

    Mureo Kasahara

  5. Department of Pediatrics, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan

    Ryoko Nakajima-Yamaguchi & Kazuko Kudo

Authors
  1. Keisuke Kato
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  2. Yasuko Kojima
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  3. Chie Kobayashi
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  4. Kazumasa Mitsui
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  5. Ryoko Nakajima-Yamaguchi
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  6. Kazuko Kudo
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  7. Toshihiro Yanai
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  8. Ai Yoshimi
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  9. Tomohei Nakao
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  10. Tomohiro Morio
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  11. Mureo Kasahara
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  12. Kazutoshi Koike
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  13. Masahiro Tsuchida
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Corresponding author

Correspondence to Keisuke Kato.

Additional information

K. Kato and Y. Kojima are contributed equally to this work.

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Kato, K., Kojima, Y., Kobayashi, C. et al. Successful allogeneic hematopoietic stem cell transplantation for chronic granulomatous disease with inflammatory complications and severe infection. Int J Hematol 94, 479–482 (2011). https://doi.org/10.1007/s12185-011-0932-6

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  • DOI: https://doi.org/10.1007/s12185-011-0932-6

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