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Common genetic variants at 1q22 and 10q23 and gastric cancer susceptibility in a Korean population

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Tumor Biology

Abstract

Genetic variants at 1q22 and 10q23 were identified as genetic markers of both gastric cancer and esophageal squamous cell carcinoma susceptibility by two genome-wide association studies. The aim of this study was to determine whether rs4072037A > G in MUC1 at 1q22 and rs2274223A > G in PLCE1 at 10q23 are associated with a risk of gastric cancer in a Korean population. We conducted a large-scale case–control study of 3,245 patients with gastric cancer and 1,700 controls. The allele frequencies of rs4072037G and rs2274223G were 11.2 and 25.5 % among patients with gastric cancer, compared with 12.8 and 26.4 %, respectively, among controls. We found that the rs4072037 AG genotype was significantly associated with a reduced risk of gastric cancer [odds ratios (OR) = 0.78; 95 % confidence interval (CI) = 0.67–0.91 for AG vs AA]. Compared with the rs2274223 AA genotype, we found a significant association between the rs2274223 AG genotype and a weakly reduced risk of gastric cancer (OR = 0.87; 95 % CI = 0.76–0.99 for AG vs AA). Our data suggest that genetic variants at 1q22 and 10q23 play a role in gastric carcinogenesis.

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Acknowledgments

This study was supported by grant no. 0720570 from the National R&D Program for Cancer Control, Ministry for Health and Welfare, Republic of Korea.

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Authors and Affiliations

  1. Department of Preventive Medicine, Chonnam National University Medical School, 5, Hak 1-dong, Dong-gu,, Gwangju, 501-746, South Korea

    Hye-Rim Song, Sun-Seog Kweon, Jin-Su Choi & Min-Ho Shin

  2. Genome Research Center for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Hwasun, South Korea

    Hee Nam Kim

  3. Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, South Korea

    Sun-Seog Kweon

  4. Department of Hematology–Oncology, Chonnam National University Hwasun Hospital, Hwasun, South Korea

    Hyun Jeong Shim, Sang Hee Cho & Ik Joo Chung

  5. Department of Surgery, Chonnam National University Hwasun Hospital, Hwasun, South Korea

    Young-Kyu Park

  6. Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, South Korea

    Soo Hyun Kim

  7. Department of Pathology, Chonnam National University Medical School, Gwangju, South Korea

    Yoo-Duk Choi

  8. Department of Clinical Pathology, Gwangju Health College, Gwangju, South Korea

    Kyung Woong Joo

Authors
  1. Hye-Rim Song
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  2. Hee Nam Kim
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  3. Sun-Seog Kweon
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  4. Jin-Su Choi
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  5. Hyun Jeong Shim
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  6. Sang Hee Cho
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  7. Ik Joo Chung
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  8. Young-Kyu Park
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  9. Soo Hyun Kim
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  10. Yoo-Duk Choi
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  11. Kyung Woong Joo
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  12. Min-Ho Shin
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Correspondence to Min-Ho Shin.

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Song, HR., Kim, H.N., Kweon, SS. et al. Common genetic variants at 1q22 and 10q23 and gastric cancer susceptibility in a Korean population. Tumor Biol. 35, 3133–3137 (2014). https://doi.org/10.1007/s13277-013-1409-4

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  • DOI: https://doi.org/10.1007/s13277-013-1409-4

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