Clinical significance of the human acid phosphatases: A review

doi:10.1016/0002-9343(74)90630-5

The American Journal of Medicine

Volume 56, Issue 5, May 1974, Pages 604-616

https://doi.org/10.1016/0002-9343(74)90630-5 Get rights and content

Abstract

During the past three decades we have witnessed significant developments in the clinical application and interpretation of both serum and tissue acid phosphatases. The human prostate is particularly rich in this enzyme, and serum enzyme levels are a useful tool in the diagnosis and management of prostatic diseases. Alterations of serum enzyme activity are not, however, unique to prostatic disorders and are seen in a wide variety of other diseases, particularly in Gaucher's disease and nonprostatic malignancies with bone involvement. It is now apparent that acid phosphatases represent a heterogeneous group of enzymes containing many isoenzymes, each specific for one type of tissue. Determination of the serum isoenzyme pattern is often a valuable aid in directing the physician's attention to one particular tissue; moreover, the isoenzyme pattern may show abnormalities in the face of normal total serum enzyme. The present trend in study of the acid phosphatases includes the combined use of biochemical, histochemical, electrophoretic, electron microscopic and immunologic technics to further our understanding of the relationship between these isoenzymes and the cellular and subcellular fractions of various tissues. Such studies will lead to a further understanding of the function of acid phosphatases and may serve to extend the clinical application of these enzymes.

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Citation Excerpt :
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^☆: This study was supported by U.S. Public Health Service Grant AM-16501 from the National Institutes of Arthritis, Metabolic and Digestive Diseases; and by U.S. Army Contract No. DADA 17-73-C-3041.

¹: From the L. C. Jacobson Blood Center, Division of Hematology, Scripps Clinic and Research Foundation, La Jolla, California 92037.

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Clinical significance of the human acid phosphatases: A review☆

Abstract

J Urol

J Urol

J Biol Chem

J Urol

J Urol

J Biol Chem

Am J Med

Clin Chim Acta

J Urol

J Urol

Adv Clin Chem

J Urol

J Urol

Biochim Biophys Acta

Clin Chim Acta

J Biol Chem

Clin Chim Acta

J Biol Chem

J Biol Chem

J Urol

J Urol

Arch Biochem Biophys

Biochim Biophys Acta

Biochim Biophys Acta

J Urol

Am J Med

J Urol

J Urol

Phosphoric esterase of blood

Biochem J

Uber Phosphatstoffwechsel. I. Mitteilung: Uber Hexosephosphatasen in menschlichen Organen und Korperflussigkeiten

Biochem Ztschr

The phosphatase activity of spleen extracts

Biochem J

Über Harn- und Blutphosphatase

Naturwissenschaften

Prostataphosphatase

Z Physiol Chem

Prostataphosphatase

Z Physiol Chem

Increased phosphatase tase activity of bone at site of osteoplastic metastases secondary to carcinoma of prostate gland

Am J Cancer

An “acid” phosphatase occurring in the serum of patients with metastasizing carcinoma of the prostate gland

J Clin Invest

Acid phosphatase and functional activity of the prostate (man) and preputial glands (rats)

Adult phosphatase levels in prepubertal rhesus prostate tissues after testosterone propionate

Determination of serum “acid” phosphatase activity in differentiating skeletal metastases secondary to prostatic carcinoma from Paget's disease of bone

Am J Cancer

Quantitative relations of a prostatic component (acid phosphatase) of human seminal fluid

Endocrinology

Acid phosphatase activity of the serum of normal human subjects

Erythrocyte phosphatase activity in hemolyzed sera and estimation of serum acid phosphatases

Acid phosphatase in patients with carcinoma of the prostate gland: present status

JAMA

The development of the acid phosphatase test for prostatic carcinoma

Bull NY Acad Med

Studies on prostatic cancer. I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate

Cancer Res

The estimation of prostatic phosphatase in serum and its use in the diagnosis of prostatic carcinoma

Quart J Med

Plasma and phosphatase in carcinoma of prostate and effect of treatment with stilboestrol

Br Med J

Estimation of serum acid phosphatase in the diagnosis of metastasizing carcinoma of the prostate

Can Med Assoc J

Factors leading to elevations in serum acid glycerophosphatase

Cancer

Properties of the acid phosphatases of erythrocytes and of the human prostate gland

Biochem J