Association of human immunodeficiency virus infection and autoimmune phenomena☆,☆☆
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Residual immune dysfunction under antiretroviral therapy
2021, Seminars in ImmunologyEngineering broadly neutralizing antibodies for HIV prevention and therapy
2016, Advanced Drug Delivery ReviewsCitation Excerpt :One tetravalent, bispecific CCR5 antibody blocking two alternative docking sites of R5-tropic HIV strains on the CCR5 coreceptor has demonstrated 18–57 fold improved potency with one combination demonstrating antiviral activity against virus strains resistant to each parental Ab alone [168]. Polyreactive/autoreactive antibodies have been associated with HIV-1 infection for more than 25 years [169–171], and higher frequencies of polyreactivity are found among bNAbs compared to non-neutralizing Abs [172]. Importantly, multiple studies have reported that increased polyreactivity and/or reduced solubility and increased aggregation propensity can accompany increasing breadth/potency [65,173,174].
Evolving spectrum of HIV-associated rheumatic syndromes
2015, Best Practice and Research: Clinical RheumatologyCitation Excerpt :Some case reports described hypocomplementaemia when SLE activity was the predominant feature [58,67]. In HIV infection without SLE, it is common to have low titres of ANA, but rarely are they high, or are dsDNA autoantibodies found [6,47]. Lupus nephritis was diagnosed in three people with pre-existing HIV disease in association with systemic features of SLE [48,69,70].
Diagnostic Pathology: Kidney Diseases: A volume in Diagnostic Pathology
2015, Diagnostic Pathology: Kidney DiseasesConcomitant systemic lupus erythematosus and HIV: Case series and literature review
2014, Seminars in Arthritis and RheumatismCitation Excerpt :In the majority of patients, the SLE responded to treatment with oral CS with or without hydroxychloroquine (HCQ). This group included 27 patients as shown in Table 3 [7,8,10,15,27,31,44–61]. The duration of SLE prior to the diagnosis of HIV infection ranged from 2 weeks to 204 mo (median duration 72 mo).
Differential Diagnosis and Disease Associations
2013, Dubois' Lupus Erythematosus and Related Syndromes: Eighth Edition
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This work was supported in part by funding from the National Institutes of Health (AI-62542 and AI-72658), by a grant from the New York State AIDS Institute, and by research funds from the Veteran's Administration.
- ☆☆
This work was presented in abstract form at the Northeastern Regional Meeting of the American Rheumatism Association, October 1986, and the American Rheumatism Association National Meeting, June 1987.