General obstetrics and gynecologyResistance to activated protein C as a basis for venous thromboembolism associated with pregnancy and oral contraceptives☆
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2007, American Journal of Obstetrics and GynecologyCitation Excerpt :The MTHFR mutations have been associated with neural tube defects, and other malformations. Data from several studies suggest that abnormalities in the natural anticoagulation system, such as AT deficiency, APC resistance, and protein S or C deficiency, induce varying degrees of increased risk for thrombosis in pregnancy and the puerperium (Table 2).1,57,62-65 Although heterozygous factor V Leiden and prothrombin G20210A have lower hazard ratios for thrombosis, they are by far the most commonly noted mutations associated with thrombosis and adverse outcomes in pregnancy.49,66-68
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Supported by the Swedish Medical Council (grants No. 07143 and No. 10827), King Gustaf V's 80th Birthday Trust, the King Gustaf V and Queen Victoria Trust, the Magnus Bergwall Trust, the Albert Påhlsson Trust, the Johan and Greta Kock Trust, and Malmö General Hospital Research Funds.