Formation of acetaldehyde adducts with ethanol-inducible P450IIE1 in vivo☆
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2020, DNA RepairCitation Excerpt :This is because formaldehyde crosslinks proteins to DNA via a methylene bridge that involves the exocyclic amine of DNA bases and different protein amino acids (mainly lysine, cysteine, histidine or tryptophan) (Fig. 1A, i) [7], although a recent study suggests a two carbon atoms linkage instead [8]. Acetaldehyde, a byproduct of ethanol metabolism [9], is also able to crosslink proteins to DNA. Acetaldehyde can form different types of DNA adducts with 1,N2-propano-2′-deoxyguanosine (PdG) being the most toxic one.
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2018, Trends in Molecular MedicineCitation Excerpt :This occurs when aldehyde-induced protein adducts form on cytochrome CYP2E1 and function as an autofeedback mechanism to reduce aldehyde accumulation. This limits the CYP2E1-dependent metabolism of alcohol, which can produce reactive aldehydes [17]. Conversely, reactive aldehydes can reduce the enzymatic activity of ALDH2 (e.g., 50 μM of 4-HNE in vitro) [18].
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This work was supported by DHHS Grants AA-05934, AA-03508, the Veterans Administration and the Alcoholic Beverage Medical Research and Kingsbridge Research Foundations.