Elsevier

Biochemical Pharmacology

Volume 27, Issue 10, 15 May 1978, Pages 1431-1433
Biochemical Pharmacology

Protective role of S-Adenosyl-l-methionine on liver injury induced by d-galactosamine in rats

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Abstract

A decrease of S-Adenosyl-l-methionine(SAMe) levels and of the activity of its synthesizing enzyme is demonstrated in liver of rats treated with d-galactosamine. These effects appear to be reversed by the i.m. administration of SAMe. A protective role of SAMe on liver is also obtained by SAMe treatment of intoxicated animals, as demonstrated both by the histological analysis of the liver and GOT and GPT levels in serum. The activity of SAMe, in this respect, is comparable to that one of prednisolone when the drugs are given at the daily dose of 60 mg/kg and 100 mg/kg, respectively.

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