Area postrema: site where cholecystokinin acts to decrease food intake
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Cited by (109)
Involvement of the area postrema and the nucleus tractus solitarius in the emetogenic action of emetine in rats
2020, Journal of Oral BiosciencesNeonatal overnutrition programming impairs cholecystokinin effects in adult male rats
2020, Journal of Nutritional BiochemistryCitation Excerpt :Accordingly, pups of rats fed a high-fat diet show impaired satiety induced by CCK administration [39]. In an attempt to understand how CCK modulates brain regions involved in the control of satiety, van der Kooy [40] produced thermal lesions in the area postrema that resulted in suppression of CCK action on food intake, suggesting that the area postrema may be an important site where circulating CCK acts to modulate satiety in rats. Corroborating this, it has been shown that systemic infusion of CCK induced c-Fos expression in the area postrema, indicating that this area is a receptive site for circulating CCK [41].
Presynaptically mediated effects of cholecystokinin-8 on the excitability of area postrema neurons in rat brain slices
2015, Brain ResearchCitation Excerpt :CCK receptors can be found in the central nervous system as well as internal organs (e.g. pancreas) and the peripheral nervous system (e.g. vagus nerve terminals) (Noble et al., 1999). The suppressive effect of intraperitoneal injection of CCK on food intake was attenuated in rats with thermal lesions of the area postrema, suggesting that the area postrema may be the major site where CCK acts to decrease food intake (van der Kooy, 1984). Previous studies have demonstrated that CCK can excite neurons in the area postrema (Carpenter et al., 1988; Funahashi and Adachi, 1993; Sun and Ferguson, 1997).
The gutebrain axis in obesity
2014, Best Practice and Research: Clinical GastroenterologyCitation Excerpt :Both the ARC and the brainstem are well placed to receive humoral signals due to their proximity to regions of the brain with an incomplete blood–brain barrier, such as the area postrema (AP). Interestingly, lesioning the area postrema or vagotomy diminishes the effects of multiple gut hormones [19,20]. Thus, gut hormones (as important peripheral signals of the energy status) may directly influence these brain areas after being released into the circulation and signalling through circumventricular organs.