Stimulatory (EP1 and EP3) and inhibitory (EP2) prostaglandin E2 receptors in isolated ileal smooth muscle cells
References (40)
- et al.
Prostaglandin generation from gastroduodenal mucosa; regional and species differences
Prostaglandins
(1982) - et al.
Comparative effects of galanin on isolated smooth muscle cells from ileum in five mammalian species
Life Sci.
(1992) - et al.
CCK and gastrin induce cell contraction in pig ileum by interacting with different receptor subtypes
Gastroenterology
(1992) - et al.
Central control of intestinal motility by prostaglandins: a mediator of the actions of several peptides in rats and dogs
Gastroenterology
(1985) - et al.
Galanin induces contraction of isolated smooth muscle cells from circular layer of pig ileum
Reg. Pept.
(1991) - et al.
Regional and cellular heterogeneity of cholecystokinin receptors mediating muscle contration in the gut
Gastroenterology
(1987) - et al.
Oral prostaglandin E analogues induced intestinal migrating motor complex after a meal in dogs. Evidence for a central mechanism
Gastroenterology
(1990) - et al.
Stimulatory (H1) and inhibitory (H2) histamine receptors in gallbladder muscle
Gastroenterology
(1977) - et al.
Prostaglandin biosynthesis by gastric mucosa. I. Studies in rat
Clin. Biochem.
(1984) - et al.
The effect of prostaglandins on guinea-pig isolated intestine and their possible contribution to muscle activity and tone
Br. J. Pharmacol.
(1975)
CCK-gastrin peptides induce a contraction of smooth muscle cells isolated from pig ileum by a direct myogenic effect
Gastroenterol. Clin. Biol.
Receptors on smooth muscle cells: characterization by contraction and specific antagonists
Am. J. Physiol.
Specific opiate receptors on isolated mammalian gastric smooth muscle cells
Nature
Antagonism by prostaglandins of the response of various smooth muscle preparations to sympathomimetics
Nature (London)
AH 6809 a prostanoid EP1-receptor blocking drug
Br. J. Pharmacol.
New evidence with selective agonists and antagonists for the subclassification of PGE2-sensitive (EP-) receptors
Further evidence for the existence of three subtypes of PGE2-sensitive (EP-) receptors
Br. J. Pharmacol.
New Evidence with selective agonists and antagonists for the subclassification of PGE2-sensitive (EP-) receptors
Adv. Prostagl. Thrombox. Leukotr. Res.
Evidence for the existence of three subtypes of PGE2-sensitive (EP-) receptors
Br. J. Pharmacol.
Gastric anti-secretory prostanoids: actions at different prostanoid receptors
Br. J. Pharmacol.
Cited by (37)
TRPV4 Channel Signaling in Macrophages Promotes Gastrointestinal Motility via Direct Effects on Smooth Muscle Cells
2018, ImmunityCitation Excerpt :Although NO mainly inhibits the contraction of intestinal SMCs, PGE2 has a complex effect on GI motility as it can both increase and reduce intestinal muscle tone via distinct membrane-bound G protein-coupled E-prostanoid receptors (EP1–EP4) (Wang et al., 2005). Both EP1 and EP3 are involved in PGE2-induced contraction of isolated guinea pig ileal SMCs (Botella et al., 1993) as well as PGE2-elicited contraction of small intestine in rabbits (Grasa et al., 2006; Okada et al., 2000). Consistent with the stimulatory effect of EP1 and EP3 on intestinal motility, application of PGE2 directly to freshly isolated colonic SMCs elicited a robust [Ca2+]i response that was severely attenuated by EP1 receptor antagonist SC 51089 (SC510) and EP3 receptor antagonist L-798106 (L798) but not EP2 receptor antagonist PF 04418948 (PF044) and EP4 receptor antagonist L-161982 (L161) (Figure S4).
Contraction of gut smooth muscle cells assessed by fluorescence imaging
2015, Journal of Pharmacological SciencesCitation Excerpt :We observed that stimulation with 5-HT, SP, histamine and PGE2 resulted in a concentration-dependent decrease in SMC length in the present study. These result of 5-HT and PGE2 obtained by the cell imaging method is consistent with previous data obtained using the conventional method (17,18). Although the effects of SP, histamine and KCl on SMCs have not been fully described, here we confirmed contraction of SMC by histamine, SP and high KCl in isolated murine SMC.
PGE<inf>2</inf> receptors and their intracellular mechanisms in rabbit small intestine
2006, Prostaglandins and Other Lipid MediatorsProstaglandin ep receptor subtypes have distinctive effects on jejunal afferent sensitivity in the rat
2000, GastroenterologyCitation Excerpt :However, the significant plateau response to 17-phenyl-ω-trinor-PGE2 and sulprostone implies that there may also be an EP1 or EP3 component to the plateau response. EP1 and EP3 receptors have been demonstrated to mediate muscle contractions in the gastrointestinal tract via direct actions on the muscle, and EP2 receptors cause muscle relaxation.26 However, in the guinea pig ileum, a contractile response to misoprostol arises from activation of neuronal receptors, suggesting that these receptors on enteric neurons may be of the EP2 subtype.27
Investigation of 5-HT<inf>3</inf> receptor-mediated contraction in guinea-pig distal colon
1996, European Journal of Pharmacology