Expression of class II molecules on intestinal epithelial cells in humans: Differences between normal and inflammatory bowel disease*
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2019, ImmunityCitation Excerpt :To assess the potential for ISC compartment interactions with T cells after transplantation, we evaluated the expression of major histocompatibility complex (MHC) class I and class II on ISCs and Paneth cells (Figures 3C–3E). The intestinal epithelium has long been known to express both MHC classes I and II, with some more recent efforts focused on characterizing this within the ISC compartment (Agudo et al., 2018; Biton et al., 2018; Groh et al., 1996; Mayer et al., 1991; Perera et al., 2007; Wosen et al., 2018). After whole-mount staining and 3D imaging, MHC class I was clearly expressed on all nucleated cells in the lamina propria and the epithelial layer.
Canine primary jejunal and colonic epithelial cells predominantly express TLR5 and TLR9 but do not change TLR expression pattern after stimulation with certain Toll-like receptor ligands
2018, Veterinary Immunology and ImmunopathologyCitation Excerpt :We recently demonstrated that canine IECs express MHC II in vivo (Junginger et al., 2014) which is in accordance with a previous study (German et al., 1998). This phenomenon is also reported for primates and humans, and human IECs show elevated MHC II expression in the context of inflammatory enteropathies (Mayer et al., 1991; Pan et al., 2012). These findings implicate IECs to share some functional properties with antigen-presenting cells (German et al., 1998; Pan et al., 2012).
Role of Epithelial Cells in Antigen Presentation
2015, Mucosal Immunology: Fourth Edition
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Supported by grants from the U.S. Public Health Service (AI 23504, AI 24671, and CA 41583), the Burrill B. Crohn Foundation, and the National Foundation for Ileitis and Colitis. Dr. Mayer is a recipient of an Irma T. Hirschl Career Trust Award.