Cholera toxin-induced small intestinal secretion has a secretory effect on the colon of the rat
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Cited by (39)
Modifications of cholera toxin subunit B binding to human large intestinal epithelium. An immunohistochemical study
2018, Microbial PathogenesisCitation Excerpt :The suggested heterogeneity between goblet cell populations is supported by the results in the present study since the anti-MUC2 antibody stained the entire cytoplasm in goblet cells from the soft palate but only the supranuclear region in the goblet cells from the colon. Nocerino et al. [8] suggested that cholera toxin in the rat jejunum affects a neuronal pathway that induces secretion in the colon. A disruption of goblet cell microbial sensing that open colonic goblet cell associated passage has been reported [12].
Calcimimetic R568 inhibits tetrodotoxin-sensitive colonic electrolyte secretion and reduces c-fos expression in myenteric neurons
2018, Life SciencesCitation Excerpt :Several in vivo studies further strengthen the concept that important connections exist between the myenteric and submucosal plexus and suggest that there is coordination of motility and secretion in the intestine [25,26]. In addition, secretory responses evoked by cholera toxin in the intestinal lumen appear to be mediated by neural pathways that involve the myenteric plexus [27,28]. In the present study, we noted that stripping off of the myenteric plexus reduced the TTX-sensitive neuronally-mediated Isc by ~ 30%.
Pathophysiological Mechanisms of Gastrointestinal Toxicity
2018, Comprehensive Toxicology: Third EditionPathophysiological Mechanisms of Gastrointestinal Toxicity
2010, Comprehensive Toxicology, Second EditionRotavirus Infection of Murine Small Intestine Causes Colonic Secretion via Age Restricted Galanin-1 Receptor Expression
2010, GastroenterologyCitation Excerpt :Remote secretion in the untreated colon has been shown in studies with cholera toxin. In a rat model, Nocerino et al34 showed that addition of cholera toxin to the jejunal loop led to increased secretion locally but also remotely in the colon not exposed to the cholera toxin. Distal secretory effect of cholera toxin was abolished by intestinal transection immediately below the jejunum, thus interrupting the anatomical continuity of the ENS. Direct evidence for activation of ENS by cholera toxin was shown by increased immunohistochemical expression of the fos oncogene product, a marker of nervous activity.35