Sensitization to painful distention and abnormal sensory perception in the esophagus☆
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Cited by (93)
Noncardiac Chest Pain: Gastroesophageal Reflux Disease
2010, Medical Clinics of North AmericaCitation Excerpt :This group reported a lower threshold of pain sensation in the proximal esophagus compared with the other esophageal segments and postulated that the proximal esophagus might have a larger number of mechanoreceptors than the distal esophagus with distention in the proximal esophagus contributing to the generation of symptoms during a reflux.17 The priming of the esophagus after exposure to gastric content was evaluated by Fass and colleagues18 and DeVault19 who unlike Mehta and colleagues20 and Peghini and colleagues21 found no accentuation of mechanical stimulation after acid exposure. Sarkar and colleagues22 demonstrated induction of hypersensitivity in the proximal esophagus after exposure of distal esophagus to hydrochloric acid suggesting that the latency of esophageal evoked potential is reduced thus leading to visceral hypersensitivity.
Altered esophageal sensory-motor function in patients with persistent symptoms after Nissen fundoplication
2007, American Journal of SurgeryProton pump inhibitor-refractory gastroesophageal reflux disease: Challenges and solutions
2018, Clinical and Experimental GastroenterologyWhat is the future of impedance planimetry in gastroenterology?
2018, Journal of Neurogastroenterology and MotilityDeterminants of the Association between Non-Cardiac Chest Pain and Reflux
2017, American Journal of GastroenterologyEsophageal hypersensitivity in noncardiac chest pain
2016, Annals of the New York Academy of Sciences
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Presented at the 1992 annual meeting of the American Gastroenterological Association and published in abstract form (Gastroenterology 1992;102:A483).
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Dr. Mehta was supported by a joint grant from the British Digestive Foundation and the British Heart Foundation.