Molecularly defined HLA-DR2 alleles in ulcerative colitis and an antineutrophil cytoplasmic antibody-positive subgroup☆,☆☆
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2005, Mucosal Immunology, Two-Volume SetInflammatory bowel disease: II. Gene mapping
2001, Molecular Genetics and MetabolismSusceptibility to severe ulcerative colitis is associated with polymorphism in the central MHC gene IKBL
2000, GastroenterologyCitation Excerpt :While genomewide searches have identified several loci in linkage with the disease,18-21 case-control studies have shown an association between UC and HLA class II genes, especially DRB1*01031,3,6-10 and DRB1*15.2,5,8,9 Association with DRB1*0103 has proved to be the stronger, and all studies testing for DRB1*0103 in UC have resulted in a significant association,1,3,6-10 whereas DR2 or DRB1*1501 (a subtype of DR2) studies have obtained mixed results, many of them failing to find a significant association.1,3,7,22 Some studies have also stressed the clinical heterogeneity of UC and looked for associations between HLA genes and the clinical phenotype of the disease.
The Mexican consensus on the diagnosis and treatment of ulcerative colitis
2018, Revista de Gastroenterologia de Mexico
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This work was supported in part by a grant to Children's Hospital of Pittsburgh from the Scaife Family Foundation.
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Portions of this work were presented in abstract form at the Basic Research and Clinical Implications in IBD conference, Victoria, British Columbia, Canada, April 4–6, 1994, and the annual meeting of the American Gastroenterological Association, New Orleans, Louisiana, May 18, 1994.