Gastroenterology

Gastroenterology

Volume 108, Issue 2, February 1995, Pages 423-427
Gastroenterology

Molecularly defined HLA-DR2 alleles in ulcerative colitis and an antineutrophil cytoplasmic antibody-positive subgroup,☆☆

https://doi.org/10.1016/0016-5085(95)90069-1Get rights and content

Abstract

Background/Aims: Although HLA-DR2 is associated with Japanese ulcerative colitis, data regarding an HLA-DR2 association in other populations are conflicting. A recent study suggests that HLA-DR2 is only associated with antineutrophil cytoplasmic antibody-positive ulcerative colitis. The aim of this study was to determine whether HLA-DR2 or the molecularly defined alleles within the HLA-DR2 group are associated with ulcerative colitis or a perinuclear antineutrophil cytoplasmic antibody-positive subgroup. Methods: Unrelated white patients with a history of ulcerative colitis (n = 97) and control subjects matched to patients for Jewish ethnicity and sex (n = 149) were studied. An immunofluorescence assay was used to detect perinuclear antineutrophil cytoplasmic antibodies. A molecular, DNA-based method was used to perform HLA-DR2 typing. Results: HLA-DRB11601 was present in 11 of 149 controls and 1 of 97 patients (P = 0.031, corrected P, not significant; Fisher's Exact Test). There were no other significant differences between ulcerative colitis or ulcerative colitis stratified by perinuclear antineutrophil cytoplasmic antibody status and controls. Conclusions: The HLA-DR2 group of alleles is not associated with ulcerative colitis or a perinuclear antineutrophil cytoplasmic antibody-positive subgroup. The unexpected finding of a decreased frequency of HLA-DRB11601 in ulcerative colitis should be further investigated.

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      While genomewide searches have identified several loci in linkage with the disease,18-21 case-control studies have shown an association between UC and HLA class II genes, especially DRB1*01031,3,6-10 and DRB1*15.2,5,8,9 Association with DRB1*0103 has proved to be the stronger, and all studies testing for DRB1*0103 in UC have resulted in a significant association,1,3,6-10 whereas DR2 or DRB1*1501 (a subtype of DR2) studies have obtained mixed results, many of them failing to find a significant association.1,3,7,22 Some studies have also stressed the clinical heterogeneity of UC and looked for associations between HLA genes and the clinical phenotype of the disease.

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    This work was supported in part by a grant to Children's Hospital of Pittsburgh from the Scaife Family Foundation.

    ☆☆

    Portions of this work were presented in abstract form at the Basic Research and Clinical Implications in IBD conference, Victoria, British Columbia, Canada, April 4–6, 1994, and the annual meeting of the American Gastroenterological Association, New Orleans, Louisiana, May 18, 1994.

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