Spontaneous intestinal inflammation and nitric oxide metabolism in HLA-B27 transgenic rats☆
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Cited by (82)
Treatment of Active Crohn's Disease With an Ordinary Food-based Diet That Replicates Exclusive Enteral Nutrition
2019, GastroenterologyCitation Excerpt :We used adult (36- to 40-week-old) heterozygous HLA-B27 (B27) and HLA-B7 (B7) transgenic rats of a Piebald-Virol-Glaxo background. B27 rats express the human major histocompatibility complex class I HLA-B27 gene and the associated human β2-microglobulin gene and develop inflammation throughout their gastrointestinal tract, including the ileum.15 They do not present gut inflammation in a germ-free environment16 and severity of ileitis is decreased by antibiotic treatment.17
Pathophysiological Mechanisms of Gastrointestinal Toxicity
2018, Comprehensive Toxicology: Third EditionPathophysiological Mechanisms of Gastrointestinal Toxicity
2010, Comprehensive Toxicology, Second EditionEffects of the non-peptidyl low molecular weight radical scavenger IAC in DNBS-induced colitis in rats
2009, European Journal of PharmacologyRole of blood- and tissue-associated inducible nitric-oxide synthase in colonic inflammation
2007, American Journal of PathologyCitation Excerpt :Based on research dealing with the biological actions of NO throughout the past 3 decades, it is widely accepted that the cellular origin and amounts of NO produced during inflammation determine the quality and magnitude of the responses elicited by NO, with small amounts of NO generated by endothelial NOS exerting an anti-inflammatory response whereas large fluxes of macrophage-derived NO mediate a proinflammatory response.1 Previously published findings in animal models of gut inflammation tend to support this view inasmuch as in vivo and in vitro experiments using pharmacological antagonists or inhibitors and genetic manipulation to ablate the effects of iNOS4,5 have shown significant protection against the inflammatory and tissue injury-inducing effects of different inflammatory stimuli, including DSS and immunological models.4,7,13 However, not all experimental models of intestinal inflammation show similar results.
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Supported by grant DK 47663 from the National Institutes of Health.