Alimentary tractProphylactic mesalamine treatment decreases postoperative recurrence of Crohn's disease☆,☆☆
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Surgical Considerations in the Treatment of Small Bowel Crohn’s Disease
2017, Journal of Gastrointestinal SurgeryPost-operative recurrence in Crohn's disease: Critical analysis of potential risk factors. An update
2015, SurgeonCitation Excerpt :The objective is therefore to assess whether there is an effective pharmacological prophylaxis. Several randomized trials have shown that mesalamine is effective not only in reducing the incidence of POR, but also mitigating the severity of the lesions.4,15,43,94–97 In a study, involving 110 patients who underwent bowel resection for CD and who were randomly divided into 2 groups (group A: patients treated with mesalamine −2.4 g/die-; Group B: untreated patients), Caprilli et al. reported significantly lower recurrence rates at 6, 12 and 24 months in the group of treated patients (P = 0.002).
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Supported by a grant from the Ontario Ministry of Health and by Interfalk Canada, Mount Sinai Hospital, and the Mayo Research Foundation.
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Presented at the annual meeting of the American Gastroenterological Association in New Orleans, Louisiana, May 1994.