The pruritus of cholestasis: Potential pathogenic and therapeutic implications of opioids
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Cited by (101)
Management of Pruritus in Primary Biliary Cholangitis: A Narrative Review
2017, American Journal of MedicineCholestatic liver disease
2014, Medical Clinics of North AmericaCitation Excerpt :In case series, drug-induced hepatic dysfunction has been reported in up to 12% of cholestatic patients.45 Opioid antagonists, such as naltrexone, are important mediators of itch and have been studied as treatment for cholestatic pruritus.46–51 Naltrexone may be used at a dose of 50 mg/d, or nalmefene at 4 to 240 mg/d. Problems with opiate withdrawal–type reactions have been noted, however, and this risk should be reviewed with the patient.
Care of the Cholestatic Patient
2013, Clinics in Liver DiseaseCitation Excerpt :In case series, drug-induced hepatic dysfunction has been reported in up to 12% of patients with cholestasis.37 Opioid antagonists, such as naltrexone, have been studied as treatment of cholestatic pruritus.38–43 Naltrexone may be used at a dose of 50 mg/day or nalmefene, 4 to 240 mg/day.
Primary sclerosing cholangitis
2012, Blumgart's Surgery of the Liver, Biliary Tract and PancreasSugammadex use in a patient with chronic renal failure
2011, Revista Colombiana de AnestesiologiaEffectiveness of naltrexone in the treatment of severe pruritus
2011, Revista Colombiana de Anestesiologia
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Dr. Jone's current address is: Department of Gastrointestinal and Liver Diseases, Academic Medical Center, Melberdreef 9, 1105 AZ Amsterdam Zuidoost, The Netherlands.