Elsevier

Life Sciences

Volume 51, Issue 24, 1992, Pages 1843-1849
Life Sciences

Non-right sidedness: An association with lower IL-2 production

https://doi.org/10.1016/0024-3205(92)90035-NGet rights and content

Abstract

Using a laterality questionnaire, 138 normal healthy individuals were classified as right-sided and 25 as non-right side. Interleukin-2 (IL-2) was generated from whole blood obtained from these subjects using mitogen (PHA) stimulation. IL-2 was quantitated in picograms/ml using an enzyme immunoassay (ELISA). Additionally, sera from these subjects were tested for 7 autoantibodies by standard serological methods. As compared to right sided subjects, non-right sided individuals had significantly lower IL-2 production. Non-right sided individuals with autoantibodies had significantly lower IL-2 production than right sided subjects with or without autoantibodies, but did not differ significantly from their non-right sided counterparts without autoantibodies. These data support the increasing evidence for the differential and lateralized regulation of immune functions by the right and left cerebral regions.

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  • The Production and Effects of Cytokines Depend on Brain Lateralization

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    The percentage of various T-cell subpopulations was similar in left- and right-handed individuals with the exception of the percentage of suppressor inducer cells that were lower in left-handers [39]. Chengappa et al. [40] reported a lower in vitro production of IL-2 by blood cells from non-right-sided as compared to right-sided individuals. The influence of lateralization on immune reactivity, and especially on cytokine production, should now be studied in humans since it is clearly established in laboratory animals.

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