Morphometric distinction of low- and high-grade dysplasias in gastric biopsies

doi:10.1016/0046-8177(89)90094-4

Human Pathology

Volume 20, Issue 9, September 1989, Pages 839-844

https://doi.org/10.1016/0046-8177(89)90094-4 Get rights and content

Abstract

Substantial agreement has previously been demonstrated between qualitative and morphometric grading of gastric dysplasia. In the present study, a further attempt is made to quantitatively define the dysplastic changes in relation to associated benign or malignant changes of gastric mucosa. In total, 232 cases were studied and were associated with benign peptic ulcer (89 cases), histologically proven gastric cancer (88 cases), and gastritis-associated mild, moderate, and severe dysplasias (55 cases). The analysis showed that one discriminant function consisting of seven morphometric features is sufficient to separate the regenerative and cancer-associated cases. The classification results obtained on the basis of this discriminant function in both training and testing sets are encouragingly similar, indicating that the classification is reliable. This was further confirmed by the results of the application of this rule in the mild, moderate, and severe dysplasia biopsies (the above-mentioned gastritis-associated cases) used in a previous study. The quantitative analysis permits two grades, instead of three, to be distinguished: low-grade and high-grade dysplasias.

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Original contributionMorphometric distinction of low- and high-grade dysplasias in gastric biopsies

Abstract

Hum Pathol

Camp Brom Res

Gastric dysplasia: A stereological and morphometrical assessment

J Pathol

Precursors of early gastric cancer

Histological diagnosis of biopsied gastric mucosae with special reference to that of borderline lesions

Gann Monogr Cancer Res

Histopathology of gastric dysplasia: Correlation with gastric juice chemistry

Am J Surg Pathol

Gastric mucosal dysplasia: Preliminary results of a prospective study of patients followed for periods of up to six years

Gastric dysplasia. Significance and pathologic criteria

Cancer

Preneoplastic lesions of the stomach

Histological classification of precancerous lesions of the gastrointestinal tract

Original contribution
Morphometric distinction of low- and high-grade dysplasias in gastric biopsies