Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate

doi:10.1016/0092-8674(82)90157-X

Cell

Volume 29, Issue 2, June 1982, Pages 403-415

https://doi.org/10.1016/0092-8674(82)90157-X Get rights and content

Abstract

Duck hepatitis B virus, a DNA virus closely related to human hepatitis B virus, was studied in infected duck liver. Subviral particles resembling the viral nucleocapsid cores were isolated from persistently infected liver and shown to have a DNA polymerase activity that utilizes an endogenous template and synthesizes both plus- and minus-strand viral DNA. Synthesis of the viral minus-strand DNA utilized an RNA template that was degraded as it was copied. Viral plus-strand synthesis occurred on the completed minus-strand DNA. A pathway for the replication of the DNA genome of hepatitis B-like viruses by reverse transcription of an RNA intermediate is proposed.

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Cell

ArticleReplication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate

Abstract

Biochim. Biophys. Acta

Cell

Cell

Anal. Biochem.

Prog. Nucl. Acids Res.

Biochim. Biophys. Acta

Viral DNA synthesized in vitro by avian retrovirus particles permeabilized with melittin. II. Evidence for a strand displacement mechanism in plus-strand synthesis

J. Virol.

State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and -negative liver diseases

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J. Virol.

Structure of murine sarcoma virus DNA replicative intermediates synthesized in vitro

J. Virol.

Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli

Nature

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J. Virol.

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J. Virol.

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Article
Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate