T-cell-directed hepatocyte damage in autoimmune chronic active hepatitis
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Cited by (87)
Autoimmune Hepatitis: Pathophysiology
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2016, Journal of AutoimmunityTransplantation for Autoimmune Hepatitis
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2013, The LancetPSC, AIH and overlap syndrome in inflammatory bowel disease
2012, Clinics and Research in Hepatology and GastroenterologyCitation Excerpt :HLA-DRB1 is also one of the most extensively studied genes in IBD [131,132]. The liver injury is a result of a cell-mediated immunological attack against liver-specific antigenic sequences [133–136] and is most pronounced in the portal/periportal areas. The liver disease in AIH/IBD follows an independent course to that of intestinal inflammatory activity and these patients also aberrantly express MAdCAM-1 on the hepatic endothelium [37].
Pathogenesis of autoimmune hepatitis
2011, Best Practice and Research: Clinical GastroenterologyCitation Excerpt :Such involvement was later confirmed by the observation that hepatocytes carrying IgG on their surface were susceptible to damage by lymphocytes from healthy individuals [68]. In the early 90s, clonal analysis studies showed that cytotoxicity against liver-specific antigens could also be detected within the T-cell compartment [72]. Studies conducted later by Wen et al demonstrated that AIH children have a 10-fold higher frequency of liver antigen-specific precursors in their circulation when compared to healthy subjects [73].