ARTICLESAn explanation for gallstones in normal-weight women: slow intestinal transit
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Cited by (102)
Sodium butyrate alleviates cholesterol gallstones by regulating bile acid metabolism
2021, European Journal of PharmacologyCitation Excerpt :A gallstone cohort study to identify gallbladder cancer etiology found that among the 4,726 enrolled women, approximately 60% were obese, 30% were overweight, and 9% were normal weight (body mass index < or = 25 kg/m2) (Koshiol et al., 2020). In a population survey, among 48 women diagnosed with gallstones, 15 women were normal weight (Heaton et al., 1993). Hypercholesterolemia is considered an independent risk factor for CGS, while obesity is only a synergistic factor (Sheng et al., 2020).
Triglycerides and gallstone formation
2010, Clinica Chimica ActaCholesterol gallstone disease
2006, LancetCitation Excerpt :Slow intestinal transit can increase the rates of deoxycholic acid formation; indeed, impaired intestinal motility as well as increased biliary deoxycholate levels are found in some patients with cholesterol gallstone disease.25,69 Evidence for a causal relation between impaired intestinal motility, deoxycholate formation and bile lithogenicity comes from studies in humans70 and mice.71 First, patients with cholesterol gallstones have increased amounts of Gram-positive anaerobic bacteria and increased 7α-dehydroxylating activity in their caecum, with subsequent higher levels of biliary deoxycholate compared with controls.72
Crossover clinical trial to determine the effect of manual acupuncture at siguan points (Bilateral LI4 and LR3) on intestinal motility in healthy subjects
2007, American Journal of Chinese MedicineNovel insights into the pathogenic impact of diabetes on the gastrointestinal tract
2022, European Journal of Clinical Investigation